ID A0A0H5S5L0_BRUMA Unreviewed; 1755 AA.
AC A0A0H5S5L0;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Bm5564, isoform a {ECO:0000313|EMBL:CRZ23909.1};
DE SubName: Full=Bm5564, isoform b; Bm5564, isoform d; Bm5564, isoform c; Bm5564, isoform d; Bm5564, isoform d {ECO:0000313|WBParaSite:Bm5564a.1};
GN Name=bma-rme-2 {ECO:0000313|WormBase:Bm5564a};
GN Synonyms=bma-lrx-1 {ECO:0000313|WormBase:Bm5564a};
GN ORFNames=Bm5564 {ECO:0000313|EMBL:CRZ23909.1,
GN ECO:0000313|WBParaSite:Bm5564a.1, ECO:0000313|WormBase:Bm5564a},
GN BM_Bm5564 {ECO:0000313|EMBL:CRZ23909.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ23909.1};
RN [1] {ECO:0000313|EMBL:CRZ23909.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23909.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ23909.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ23909.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm5564a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; LN856931; CRZ23909.1; -; Genomic_DNA.
DR STRING; 6279.A0A0H5S5L0; -.
DR EnsemblMetazoa; Bm5564a.1; Bm5564a.1; WBGene00225825.
DR WBParaSite; Bm5564a.1; Bm5564a.1; WBGene00225825.
DR WormBase; Bm5564a; BM38396; WBGene00225825; Bma-rme-2.
DR OrthoDB; 2943710at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 11.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 322..361
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 458..500
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 501..546
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 547..589
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 645..683
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 961..1003
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1317..1356
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1646..1681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1664..1679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1421..1436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1755 AA; 194969 MW; 3F1BEAFF6FB30C67 CRC64;
MKANLFTIAM YYALIERAVL TKVPVLARQR KTITQLTLDI DKTVITSATE IVSGIDESFP
VLIALDFSRN ILAYMESWQR SSSGNIRVIA LDNSTVPSYI QRSSGVAEET VTSLAIDWVT
GKLYVGVETA SIHNAGRIEV CPLDGQTTCA IALHSSFENL NSRVDALHSL VLDPVDGYMY
WLNRVHKRIE RAWMDGRHHD PHCFKDDTIG VVATSALTLE QVSRMLYYVR TRTSLDESQI
WSCSLYDRES CRTVASKVNA FYLDVFSDYL IWTSVTNQNS GITVCEKMDC DRTTREMINS
SGVEALVVFD EEVQPLKQSL NPCESKNGGC SHICVLIPGA PWRSCLCPVG VRLLQDRLTC
SPNGIESLLY VATTSGLIFI SLDTAHHTPL PLPNVASEIR DTKVVHIDFD PIDKKLFMID
GDMGVIRRCN PDGTGMEVFV EDSDKLVSDA LAVDWLNRNL YWLDSNVAQI KMQSLSSKGR
QIVISHGLKQ PRGLALDPDG GYMFFSDWHE STSRIEKAWL DGSHRRVLVS LEKNAWPNGI
VVDARHKRLY WAEGSRSFIK SVAVDGTLDV QVFAESVNHP YSLTILGNSL YCNSLYGRKI
SVFRVPRHNE SVLNVQLSVV SDSVIFGQMG IRAVSLNHIP EGVSPCQTSN GGCSHICVKL
PNGKRGCVCP VGYELQADNT TCILPTAFLI YTQSPAVNTA NSIMRISLET APANNHRINI
ADMTSAPVSV DINQNSQRIF WSSEGHGRSI RSLLRSAFFN GSGLETVYEG NAVNYIAVDW
ITSNIYWCNM EQRRIEMVRG DGRRHRTIAW ENIDPRYLVV HPLQRFLVFV NYYNQQKITI
NKIPLHGEQS GGQVIVQQLD TVNALAIDFE SELLVWSELN ERGGGVSISD FSGRNRVRLV
YSEQLLPVAL AVYNRQIYIA NMNSNTIDLY SGHALTVLHD GVSHVSNLVV AHAQISKGWN
GCVQNNGGCS DICVAVSGSL YNASAKCFCE DHFTFDDVGG KCLPPKHFLL VAVRSRFIRF
NLRQTDTDGV FWKNDPYSIL SITDVGTPVS VGVDLFSANR SIYWIDSNDD KVIKRSSDLS
QSMTQTITLS KHSNCAILFN LAVDEVGRQL FVSCAEHGLS HASSIHVWRI KNNDHLEYIG
VVVSGRERSV VTDRPPYPRQ IALFPRLNLL FYVDDAASIP VIVRCSLNGR QCVQWETPNL
MHTVKLHAFQ INDRLYYTTA NGLWSRDAHV FSDVRHHVKA RPSDLDMVPI NEKKLIIIAK
NESQYDDMLL ELMDDIPTVS LDELKWSTTS PFSVKHILAL TVVGSIERDF YVNLNHTCAV
SHCSHLCRVP RDSRKRHECL CPLGFGLQTP SETFCFKHTS CLHWQFKCDD GQKCIHAMAK
CDGHYDCADG SDESSHWCGN IAFDKWPCDN RKASIARALV CNGAEDCADG SDEAHCRCTN
PLFYFDCTFG LNAALHPAEC IRRELICNGI NNCYAGQDEE KQLCAEFVAT VTVATAISPS
FELIIPLAVF FLALSIVSVC CCHLSKQRPP GQNLSHATTH SLPMNAEPLV LLPAHPDDTQ
IEFQLHTYSV GASSLYNALP PPNSRLSADT ISYLHSLNGS PSEKGSMLTA VAKANSRKFF
APPPSAASLS TYGVVKPAGM RVHLQHGGTV STRNRRKQRN HSRTVGITRT YSPPPSYSKV
KTTRPVHIDM GCSGEESQQL QVPTNSRIIS SIDSSSVESM GHVLLPSSNF ISSVECTHQQ
HLLDYSSTSS DVSLG
//
