ID A0A0H5SA16_BRUMA Unreviewed; 4344 AA.
AC A0A0H5SA16;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=oleoyl-[acyl-carrier-protein] hydrolase {ECO:0000256|ARBA:ARBA00012480};
DE EC=3.1.2.14 {ECO:0000256|ARBA:ARBA00012480};
GN ORFNames=Bm6983 {ECO:0000313|EMBL:CRZ25199.1,
GN ECO:0000313|WormBase:Bm6983}, BM_Bm6983 {ECO:0000313|EMBL:CRZ25199.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ25199.1};
RN [1] {ECO:0000313|EMBL:CRZ25199.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25199.1};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ25199.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ25199.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; LN856998; CRZ25199.1; -; Genomic_DNA.
DR WormBase; Bm6983; BM46841; WBGene00227244; -.
DR OMA; MCINVLP; -.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0016297; F:acyl-[acyl-carrier-protein] hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0032787; P:monocarboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF00975; Thioesterase; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 5.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 489..566
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1596..1671
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2221..2296
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3322..3397
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3936..4011
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4344 AA; 498264 MW; 44AE42CFA6601A16 CRC64;
MLPLLLLLVD GCSCNDTPFV INRVTNQVEF SELLLGYNYD HADNRSVEIP KGIKIWRPDT
NIFESVATYG AQSLRLYSDG TICWKQRATL TFPCISYFRL KQSALSTLNC SLIIGSFDNS
GAESIIYRIG DIMLPPNLNP VFTINYTIAT FQEIALNGES VIQTAIHFLI ESDQIDRYTQ
SVTGHEFSLI LQTKITLQDF EMDLKQVLLP IIIESRRRFG DNSLLLVLDS VKIDSGRMDP
EPSRKVLLES AAGLNKLELL KVLSGNSTIQ GYAGEIRYWQ TKLCQNLDKI LVNMFKIDNL
DKVQSKILQD VSVWKRKDDE VVKGGEFTTV LCFSFSNDNE YIVPDSEILT FLKYSLQVHF
ETSLLISVKE VEQIALPAAI FRQLWVAIAE SKFIKISVKL YGFDGFECGY VKGISFSENI
KRFPEEGANK AYEKTREKLG RYDNNLHESH VYDMKRIKQE IQSSTKTNIS DHCAFYDDTM
ISKSIASEAN RLSIINKIRK AVEAIVEAPC NDNRTSFISL GFDSLKLARL EFVLESEFSG
KFSIPYGSAH RHPNISALAD YILKSSIQGS SIPESKKTTN FQLLTEKLTK IVRSGAEIPL
SAAQKRLIFL HQLDIERELN FVEILKFSIK SLKIHQLQRA FNKVVARHTA LRTIYTLTGQ
TILSLTEAYF WISAECEYVW KLLKPIDLFD SFIPMRIFVT EQEDNKDNKK IKESISNEIC
QEKDQRILGK KQTMNTDIKN SNLIVIQIHH IMIDGSSIKL LTDELRIFYY EEKSLRSIPY
QYGHFVLMED QQRQNRKLYK AFWKHLLLDV TLQKLPVDET GLQAGKYSGR CLQFKIDSKI
QKSLQNLAIW CSVTQFSVLL TNFQLLQYKR YGFKDCCIGI ITAQRETSEL CTIIGCLLNV
VPLINTINPN DRIHDFITKS YKHLNESIQK QLQFDDLIAA LRLERDLPNS PLFQVLFISD
DSGDISYNDD GNESNFAQYD QVWHFQYYNE SMTLKIEYNS SRFYKNTIET MVQQYFRLLH
KMSQNLHMLI KSIKMVSSME EFMDYKLRLE NRCDFPQKCT VLNIIDEQNK MNFYGNTIIQ
RGVPFSNVFL QQKSNQLSRF LTQRWLQFLG EDMRNDSFVI LILDRSVFLL LSIFSLWKCG
IGVAPLNLET SLEQLNEILA KLSYPAVVYE CKENNVANQY ISKNFYGTML QNSEGQNSVF
GHDINEIITV ISGYSDQELR KKLTQHNLAY MTFTSGSTGT PKGICTEFYG LNNLVLNYAE
LLSIKSSSII YQVVNPSFDI FFADILEAQT NGASLYLASQ RIPDLEEMSK VTHAYIMPAY
LSVVQPEQFK KLENLEKINF GGDYIQYKVL QDAIRIGLHF HNQYGMTEHS IYSTCKLMKV
CDKTSSVGKP LKNIFFSIYD GDKNLCGQHI TGICCSSGAG ISRGYHDNEN LNQISFLNNN
DLTQLELLLN HDKRYFYSAD LAQIKSNVGQ LLFHGRSDFQ VKIRGMQVDI PTIEAVLGQN
HLVKECIVCL RRIEGEEFLI AYIISCNDII TEEEKGQLMI KSLNEYMLGK LSAFMIPSHY
VFVQQFPLNI NGKINRKLLP VPEKLLNSKI PLKTDCIFEP WEKQVIGIFA ALLPGKAIQI
DDSFFEAGGD SLKALIAIQN IKRDTGMDLQ LRDIFKLASF RAILERLKVT HSIGNHKEVE
NLTVLESAKF RPNVLQNNGR SDKLTDDQLV NNVKISDNVD NNRSLNKKMS SKYNEIYNGD
EKSRFWLNGS IPVSLQQERL LFLYSFGKEY RESYKLQFLI IFYGSVDLKV LNTALNYIMR
KHRLLRTIFF QKVAKVIQEV TSLSECYIEV CKNVFGYDVT GSEISSELPS IYDTPLLAVI
VSGNLKLMLI LDHLIVDGRS IAILTNDLVE FYNILINGGS VSFDFTEGTS YAEFCLQQRR
ELEKFRVALK GADVDLTLID RAVAKDELEV QEKWLLKLRD FPPLSLQGDL SNEEFDRRNN
VIRLKIPLYL SAIKHFCVAE RCTLFAYLLG VFSLTVRSLC DQQKHRFAVV TSALNRTSDT
INCVGLFVNT VIIPIDTAFD CVSELIHNLQ QNITEALQFQ HIPFDYIIRK LNGTRSSSGT
ESYQVSFVVQ NASATKLPRI DGVETIVEEI NAKYAKFDQA WYCTEFEDYI EVSVEYKIEK
YSDLEIKYAM ELFVQIASQL LSNRSMKVKG ILKSCELIRV EKPLNENNNS KNVNATEGTI
KKSWMLEEVL LGIWKEVLEC SEISVFDNFF AIGGHSLLIP NICYKIEQQV NYQCPPQAIF
KYQTVRELAQ HINNKQDLKI LKISNEKLKI RVCPLQESLA KMYYNAATET SISSLSTTTT
TAITITSDLI KAYQTGFSIA LKCINFSKLR HSLNLILMRH FALRATFYCQ NNDFFQQIHS
GTEIYITPRK TNIEGASLIV PNPFHAIPIL CWLIDGIKQE LPDDSYCEFH FKISHIICDG
KSLSIIAREL SNSYFEDRHI SVKDDNFIQF SRRLKQRFQE RYTEMQKFWS QNLNNTEGAN
IHYEKITATV SSNYRCKFFY KKFKSLNILI KRVAKKCYCS PFVVQLAAFS KVLSGIATQD
SKMIISCPVD MRDSRAQQCV GMCINVLPVI INSRLRNYQD LIQDIAKSFA NAYINADISN
DEIEKLCEKY GVSNFADIMI VNNYMQYSSH CYQILNDNSE FTKCTLTLFL TQYHEDIEAK
IECKQDFFYD ESMRIMLNQW AKTIRRMEKV IVTNDEIESK ERRRCPHEIF FCKEYFSVKN
MGVRSKERLA SSGCDNDENV LQKSDYPAFS YQHLLREAFV ANRQWTAMTV LTESKESINY
RTLTGLIYRT AKIIREKVAQ ITGGILRSDT VIPVIAHNSI KTLATCLAIT MTGAAYLPID
STGPAKRISN ILEQIGAKFY VTVDQLINND DEFQISFNFS FQNALEINLN NMRFDKEPLE
LPPHLQNTPN DLAYVIFTSG TTGKPKGVTI GQHGLLNMAI ACTRDFWMKP GDCVYQFTNF
AFDNSVLEIT MALINGSALL LREDFFTPHT FLNEVKHGNI THALLFPSLV NTFKDEEIGE
LRHLRYWIVG AESASKRILE CALKSGVNVI QNYGPTETTA YALTKRMKLL DRPNNIGCGI
TNVVVTVRNF CGEIVQEMGV GELCIKGIGI TRGYVISSDV IRENAEKEIE SKKFGEVDSC
CSISPGNNFG TKDMVRMQPN NEILFLGRYD KQVKIRGYRV ELGEIEAILC QYPQVKSAKV
ILKLIGQQRQ LVAFVILSDL FENRFHPAAI RHFMQQHLPY YMIPIQYHFL QQYPLTKNSK
VDVEALAMSQ NPENDQCLKH AEPENSMESM LLGFFRKVLQ NDNISVNDDF FAVGGNSFSA
TRLTELIEAN VAHCIGISNV FRHRTVRRLS QHILHFHKKS SNEIYGIQKF SGINKSDFNL
DNIPLSFQQQ QFQFLNETKE RQYYELIFVQ KFDASLSLQH LKLAFLRLIL RQPSFRTIFP
ERNFDVHQEI LSGTEVYFYS STVQRSSFPK GLVSYNENTT EEKIKILQDV EVNLKSEPPV
LCAIEVTSST SHTVILRINH IISDAWSTNL LENDLSDLYQ KVLKNKQFDS NSKLPLTYAE
YSIEQFEQKH FLEGLAAKYA DKILKWIIND PNYNNILEKW ERTEGQMNHS GLVNQNLGSR
ITSNFVHYTK STDFRNYSEA EFTFEVKKIE KICGYFETTP LVAFLSAFAS SLHELSGIDQ
LIINVAAANR SSKTNNIIGN FLNYLFINSA NNPLEKTDII SATSRNVNTT SSKSTMELSD
LSTIYASYVK KYVENIDRAV NESRQFEQVP FIPLLKLLRI KLKKLKSPSV EVLNRLHKTI
FFNFRYGLEE NRESVLGKGE TQAPMNCTYE IEVEIDRAKS YYSCRIRMKN RSSLKHTSAL
CRRMFSFLQQ MSINSNIQET TKDEIIPEEN FYLPSTNDHI VDLKLRKMWS ECLKKRWIKD
DDDFFMEGGT SLLTLKLRRL IESELKIHIE LDEIFKYSTF IQLSNLLQKR FINIAHSLSD
NTIGLMNPES RRNTDSAVQI DKKMSNKRGT SKETEILQTS GNLTTVRLLY QSESDINVTG
SAVVVFFHAL VGGVTWTYAP LIKQLMRRLP PSSSFKIIGV EHPNSFSRSS KDPKFHQSIE
SLCSKYIRDL HDDLCKVKIR LFIGASFGAI LAYQCAVQLQ QEGIHINDII SIDGTAQWRK
STSETELASY EEHHRQINKI VKYHCGGTKV DSELLEAMTE NAWELLKMMH IYIPKRSLEV
PQLHVTLLRS LAQKTSEAEE DYGWINLCSR TIIDIPFSHD TMLHDCNTDT IADIILQIIQ
KLDERQLFHR NITNVSVDKT LQII
//
