ID A0A0H5SE77_BRUMA Unreviewed; 938 AA.
AC A0A0H5SE77;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Bm4129 {ECO:0000313|EMBL:CRZ26398.1};
DE SubName: Full=Metabotropic glutamate receptor subtype 5a (MGluR5a), putative {ECO:0000313|WBParaSite:Bm4129.1};
GN Name=bma-mgl-2 {ECO:0000313|WormBase:Bm4129};
GN Synonyms=Bma-mgl-2 {ECO:0000313|WBParaSite:Bm4129.1};
GN ORFNames=Bm4129 {ECO:0000313|EMBL:CRZ26398.1,
GN ECO:0000313|WormBase:Bm4129}, BM_Bm4129 {ECO:0000313|EMBL:CRZ26398.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ26398.1};
RN [1] {ECO:0000313|EMBL:CRZ26398.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ26398.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ26398.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ26398.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm4129.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; LN857023; CRZ26398.1; -; Genomic_DNA.
DR STRING; 6279.A0A0H5SE77; -.
DR EnsemblMetazoa; Bm4129.1; Bm4129.1; WBGene00224390.
DR WBParaSite; Bm4129.1; Bm4129.1; WBGene00224390.
DR WormBase; Bm4129; BM30239; WBGene00224390; Bma-mgl-2.
DR OMA; TYVPEHP; -.
DR OrthoDB; 1331864at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15285; 7tmC_mGluR_group1; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF134; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 474..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 473..736
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 748..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 105731 MW; B1DF8959023D6FCC CRC64;
MEQSIAFLRE GVGQCSCTST PGCQKKTAPV VAVVGPAKSS TTIAVQNLLQ VFHIPQIGYG
ATTADLSDKE QYGYFMRVVP ADTWQAKLVV AMLEHFNWTY VAVVYSAGNY GEKGFEELER
MINNDLSENV CIAYSEKVKS LAEPAEFDKI LNSLSSQKSV PQVVVCFCEG LTMRGMFKAQ
QRLRRRNPEM RPFQWICSDG WNDRLDVVNG VELEAAGSFS IRIHSPHVKW FDQYYFSLNP
ENNTHNPWFR EFWQEKFSCQ FTVPKDDFET KVCTGQENLA INYKQDAKLS QVVNSIRVVG
LALQALYNDR CRENSTMCTE IFALNGTLLL KYMLNVTFVD QFNQEVYFDT NGDPPAWYDV
LNYVGGEEGF RMVGEYRKKR LGKYRLKITK SDIMFYDKTN QIPESVCSKP CKIGQRQRET
AACCWICEDC LSHQIIDYTT RTCQNCTLGW WPNDDHTTCY PLVHEGPDWS STGIILALLL
ASLGIIMTSF TVLIFIRYNH TPVVKSTTRE LSYIILSGIT ICYAVSFAVL ATPSFITCFI
SRTLPPVAFS MIYSALLTKT NRIARILAGS KKRILTKKPR FLSTASQVVI TWIVICIECV
IVAAGVMGEM PQAGFDPYYQ PQRMVLVCST TTFAFLTPFF WNLFLISLCT LYAVKTRNLP
ENFNEAKFIG FTMYCTLVVW SAFIVLHFGT TNKALTMSFS FSLSASIALV LLFFPKLYII
LLHPEKNVRA SYTTTKLIRC HFGNSQTTER TSKETNNWKS GSSQHSLSRS EAGSQIRHSC
RKRKPSVYIS QSPSQDASTQ TESSKITSKF ARTFSIISGS LGATGATNGT QREVKQLEVN
DEVQELIDSC RRYQISQSER LHGSVKNLLL VEKEEKNENI GCLIAGSMQT VLNTVSKQVL
PMGSSLPHTQ VSNEDSKFEQ LLKSCGMEPL QLTNATPL
//