ID A0A0I9N4Y8_BRUMA Unreviewed; 1581 AA.
AC A0A0I9N4Y8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=1-phosphatidylinositol-3-phosphate 5-kinase {ECO:0000256|ARBA:ARBA00012009};
DE EC=2.7.1.150 {ECO:0000256|ARBA:ARBA00012009};
GN Name=bma-ppk-3 {ECO:0000313|WormBase:Bm6086};
GN Synonyms=bma-ppk-3.2 {ECO:0000313|WormBase:Bm6086};
GN ORFNames=Bm6086 {ECO:0000313|EMBL:CTP81123.1,
GN ECO:0000313|WormBase:Bm6086}, BM_Bm6086 {ECO:0000313|EMBL:CTP81123.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CTP81123.1};
RN [1] {ECO:0000313|EMBL:CTP81123.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP81123.1};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CTP81123.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP81123.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN856924; CTP81123.1; -; Genomic_DNA.
DR WormBase; Bm6086; BM41371; WBGene00226347; Bma-ppk-3.
DR OMA; SNHRWSE; -.
DR GO; GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd15725; FYVE_PIKfyve_Fab1; 1.
DR CDD; cd17300; PIPKc_PIKfyve; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 3.50.7.10; GroEL; 1.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR044769; PIKfyve_PIPKc.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45748; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR PANTHER; PTHR45748:SF7; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF01504; PIP5K; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52029; GroEL apical domain-like; 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 182..242
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1241..1562
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
FT REGION 359..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1581 AA; 179629 MW; 650BDEEAD315BB4D CRC64;
MNILMQRFRL LLHWLNPTLF PGQRGRVREP GFIARSRGSL MREQFQGMEP TDDNTACITY
FARHPEELID ESVASTSAGI FGNLFSRIFK PSKDINIANN VRDTTTMSMS SRHDDVGEVS
DISMENEIGD TGENSKEKDE NGSDILEQRK KSYIRFASIF KGRNPGLLDY ERSNFRRYWM
PDSSGRECYE CQERFTAFRR RHHCRLCGQI FCSKCCGIQV SGSLLGYTGD LRLCTYCADI
VISNLPQTET KLEDGPNSSA CDQKLNYETD FSVSTIFAGP ISWSLNSPII ADENNESGTS
FQCTVPRKSS VKLDSPTQLS VTELAMYNSN VQYSPTHDVG DDLEPEWVKN IEMTDNVKPL
DSSNSKLESM DYSHSTSQKD DMNIENKLNF HVAEMDNEQI VKKASPSRAG NDDLRFNETI
ERCFEIQSEK LILQLFSREG LDPKEWWEII WSVSHVVSSM VKVDMEGRKN VNVMKHAHIK
NLHVAVDKPS AKVIEGTVCS KSVRHESMPN EIRNASVLTL EGSIEYERVS DKLSSIEPII
SQESEYLRNQ VERMLSHRPS VVLVERNVAG LAVQMLLRAG VTLVSNIKPR VLQRIARSTG
ADVMPSLDAQ ILNQKIGFCP FFRQEKVRLM NGKYKCLLVF EECPPELGCS VLLRSNSKRD
LRAAKRILHY GILMLYSNHL EVKLLSTCGT TLTNRSADCD ICSINAAELD TNKGNFCKRL
KKSTLSPSPL IDFGIPFLET SKGRRCSLRK FFNRFISSLA TENNGTRDCS DYKAEENYSL
KRYVHSFVKN ITLTEVDEDA ISSFRAFSGW MFRCSVHKQN RDRLRKETVS NKEIEDVLDP
FAHQHISVLF GSFCPKSPNA PLFCIRPWVV NMDYYGVNDM SLGDFLRKYC FNRAYQCPST
NCDLPMMEHS RRMVHRNVCV EITTQNYVHL SGDFSSAVAE QNDTLLTWHY CPKCKSSSAV
LPLPESVCRL SFARYLNYLA NGAYATCNIN SLLQKCDHCC FHQHERNVAL NNLVTTFKVL
LVRPFHVTFS PLVCTVEPIM FTRKFVAESK NEIEKAAAAI FKIMSEQIEN LLKYNGNSLY
STCHTQAAKI LGDARSAFNS AIKCFDPSGA LTGEPIAIRS NDAVYTQATD TICRCRYIVQ
HAINLWNEQC QYFCQQIRAI KKYSGSGILP VNFGFASIVE DNMEGNKINN EQTLLANHMQ
INAPDFELIP LESPFLAECH FGLPLPSVGL AAVVVRDMID RKGAAHPDIG SIIAYALSSV
EYNTKRRKQR DSAYNVFVEV ESVAVANYEH IEVDFADDKA QYYVKIYYAE RFHMLRKLLF
VEGEDCFIRS LNSSRSWSPQ GGKSGASFYR TQDDRFVFKQ MSRFEIQSFV KFGPNYFSYV
STAMTDNKLT TLCKVYGVYR ICYKNKSSGQ QLKVDVLVME YLFYRRNVKQ VWDLKGSQRN
RMASEGKRTA DLVLLDENLV KDLWNNQLYV HPHSKAALSM AISNDSHFLS AQHVMDYSLL
VGVDETNSEL ILGIVDYMRT YTLDKKLESW VKIVAIPGAH LPTVISPEMY CTRFFDAIDT
YFPIAPDQWT GLGSALSSSD Y
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