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Database: UniProt
Entry: A0A0I9N9K0_BRUMA
LinkDB: A0A0I9N9K0_BRUMA
Original site: A0A0I9N9K0_BRUMA 
ID   A0A0I9N9K0_BRUMA        Unreviewed;       794 AA.
AC   A0A0I9N9K0;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   05-JUL-2017, entry version 7.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=bma-vha-6 {ECO:0000313|WormBase:Bm10100};
GN   Synonyms=Bma-vha-6 {ECO:0000313|EMBL:CTP81363.1};
GN   ORFNames=Bm10100 {ECO:0000313|WormBase:Bm10100}, BM_Bm10100
GN   {ECO:0000313|EMBL:CTP81363.1};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|EMBL:CTP81363.1};
RN   [1] {ECO:0000313|EMBL:CTP81363.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CTP81363.1};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|EMBL:CTP81363.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CTP81363.1};
RA   Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA   Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; LN856962; CTP81363.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Bm10100; Bm10100; WBGene00230361.
DR   WormBase; Bm10100; BM41015; WBGene00230361; Bma-vha-6.
DR   OMA; EMAYDEI; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 3.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    386    411       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    423    446       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    523    543       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    563    584       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    619    638       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    670    691       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    726    752       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    125       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   794 AA;  91661 MW;  5B6054B26C17B0E2 CRC64;
     MGSLYRSELM SLCQLFLHSE MAYDEIAKLG ELGVVHFIDL NSEMSSLQRR FVGDLKRCDL
     LAQKLKFIEE QILADSIPIP RLNEFVPAPR PSEMNTLETE IEEIEEQLLE NNKNMKNLMN
     NYAQLNECMQ CINKVQQLLT DGQRQQARQS LLGMENPTSG IGAIRRKLTN VMIGRKDSII
     PDRMSSIFSG ENFVAGIVER CHSTALERLL WRTCGLNVFV RTVTIDFSED PLLNDITPKD
     VFMVFFSGAV LGLRVRKICK CYQAKIYDYK DPANNRVLHV TSLFGRVAEI KSIIEETRKY
     RNTLLRAAAF KAHEWDIKLQ KMTAIFMVMN MCNVDITQRY LIAECWIPTA DIIRVRKNFD
     KTGMVYYTIF VAIYPRTPWT MITFPFLFAV MFGDAGHGLI MFFVALAFIL FENKIKIDDE
     IMGSFYCGRY IILLMGLFSI YTGFIYNDFY SRSMNLFGSS WYNPYKSSLL ELTPVDMQFD
     LILPPQYAYD RDKGPYVFGL DPVWNLAENR LTFTNSMKMK ASIVFGIIQM TFGVILSLMN
     YLFVSITVKW LMFSSIPGNV FGFFYPGSHC APSLLIGLIN MCMLKPRKEG FWNRSSSSEF
     EQCYLHEWYP NQGMVEKGLL MLTVLCIPVM LLVKPIYLKF KTQKIAHDEV ANIDTYAVKF
     DFMDVMMYQG IHTIEFVLGC ISHTASYLRL WALSLAHAQL SEVLWSMVLS MAFSLNTWLG
     GPVLYLIFWL YGMLTFAILI LMEGLSTFLH VLRLHWVEFQ SKFYDGHGYS FKPFAFTQMK
     SFEIANKKDK NVIC
//
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