ID A0A0I9U3V1_9MYCO Unreviewed; 386 AA.
AC A0A0I9U3V1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:KLO36781.1};
GN ORFNames=ABH38_10175 {ECO:0000313|EMBL:KLO36781.1};
OS Mycobacterium haemophilum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=29311 {ECO:0000313|EMBL:KLO36781.1, ECO:0000313|Proteomes:UP000036334};
RN [1] {ECO:0000313|EMBL:KLO36781.1, ECO:0000313|Proteomes:UP000036334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|Proteomes:UP000036334};
RA Greninger A.L., Cunningham G., Miller S.;
RT "Genome sequence of Mycobacterium haemophilum.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLO36781.1}.
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DR EMBL; LDPR01000007; KLO36781.1; -; Genomic_DNA.
DR RefSeq; WP_047314060.1; NZ_LDPT01000004.1.
DR AlphaFoldDB; A0A0I9U3V1; -.
DR STRING; 1202450.B586_11040; -.
DR PATRIC; fig|29311.18.peg.3204; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000036334; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Reference proteome {ECO:0000313|Proteomes:UP000036334};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 3..384
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 386 AA; 40789 MW; 14F2BA60D75277BD CRC64;
MREQAMAMTG IGAVTGYGWG TKYLWEGLLS GKPAATLLGG YGQNRDEDVW LARVSDDGDP
ADGASLAARA MRAAAREAIT DALERGWTPG RQVGVVHAVV VSELEEWGRF HCEDGGQRRV
RDYLALMPST PVSLLMQEYG FHGPAMNVSA MCASGNAGIL TAKMWLDCGI VDDVVFLTTD
LSMTPETVDH FVRMGVGVVD TEPLDACRPF QEGSRGFPMG EAAVAFVLSR DSGQPYAHVL
GGAMSHDAYH VTSVDPAHTQ VEACVRQALD QAGVDAGAIR YMNAHGPGTQ QCDRAEAAIL
DEILNGRPEI YSVKPLVGHC QGAASAVELA TAAFAYEYGV IPAPPRVAPG HPRLLDGPTP
MAEGLTLKTS LGMGGHNSAV ILASLN
//
