ID A0A0I9VGE7_9MYCO Unreviewed; 443 AA.
AC A0A0I9VGE7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:KLO37153.1};
GN ORFNames=ABH38_09640 {ECO:0000313|EMBL:KLO37153.1};
OS Mycobacterium haemophilum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=29311 {ECO:0000313|EMBL:KLO37153.1, ECO:0000313|Proteomes:UP000036334};
RN [1] {ECO:0000313|EMBL:KLO37153.1, ECO:0000313|Proteomes:UP000036334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|Proteomes:UP000036334};
RA Greninger A.L., Cunningham G., Miller S.;
RT "Genome sequence of Mycobacterium haemophilum.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLO37153.1}.
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DR EMBL; LDPR01000006; KLO37153.1; -; Genomic_DNA.
DR RefSeq; WP_047313939.1; NZ_LDPT01000003.1.
DR AlphaFoldDB; A0A0I9VGE7; -.
DR STRING; 1202450.B586_12665; -.
DR PATRIC; fig|29311.18.peg.2742; -.
DR OrthoDB; 315417at2; -.
DR Proteomes; UP000036334; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR048432; MASE7.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF20967; MASE7; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000036334};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 251..378
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 443 AA; 47590 MW; FFB96C52764EC84A CRC64;
MAAKKCGAPS AGPDGSVRRP DCVAAMRTQS RDRNQHYAET TARRQRVLTI TAWLAVVVSA
SFVIVQILAD AWSWQISSIN VGAAIIFAIV PLLHRFGDLV APLTFIGAAY VSVFASCWGV
GTGSGSQFFF LVGACLVVLL LGIERIVLAS ALAALAAGLV IALEFLVPRD TGLQPAWAQS
TGFVLTTVSA CVMAVVTVWF ALRETARAEA VMEAQYDRSE ALLANMLPAS IAERLKEPDR
TVIADKYDDA SVLFADIVGF TERASSTAPA DLVRFLDQLY SAFDALVDKH CLEKIKVSGD
SYMVVSGVPR PRPDHVQVLA DFALEMADAA AGLEDPHGLA VPLRVGLAAG PVVAGVVGSR
RFFYDVWGDA VNVASRMEST DSVGRIQVPE TVYQRLKDEF VLQERGRIEV KGKGTMRTWY
LVGRKAISDS SGLPAEESRT AHV
//
