ID A0A0I9YSQ6_9MYCO Unreviewed; 1050 AA.
AC A0A0I9YSQ6;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=MFS transporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=ABH38_06590 {ECO:0000313|EMBL:KLO37829.1};
OS Mycobacterium haemophilum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=29311 {ECO:0000313|EMBL:KLO37829.1, ECO:0000313|Proteomes:UP000036334};
RN [1] {ECO:0000313|EMBL:KLO37829.1, ECO:0000313|Proteomes:UP000036334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|Proteomes:UP000036334};
RA Greninger A.L., Cunningham G., Miller S.;
RT "Genome sequence of Mycobacterium haemophilum.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000256|ARBA:ARBA00008537}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLO37829.1}.
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DR EMBL; LDPR01000004; KLO37829.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0I9YSQ6; -.
DR STRING; 1202450.B586_08300; -.
DR PATRIC; fig|29311.18.peg.1484; -.
DR Proteomes; UP000036334; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd17321; MFS_MMR_MDR_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00711; efflux_EmrB; 1.
DR PANTHER; PTHR42718:SF47; DRUG EFFLUX PUMP JEFA; 1.
DR PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07690; MFS_1; 2.
DR Pfam; PF01734; Patatin; 1.
DR PRINTS; PR01036; TCRTETB.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS51635; PNPLA; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000036334};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 24..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..470
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 519..616
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 795..955
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 478..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1050 AA; 109843 MW; 0A52B44081C0528E CRC64;
MGRPRHRGQH AAPLTQRRKP SSTAVLLVAA FGAFLAFLDS TVVNVAFPAI QRYFASQDIS
SLSWVLNAYN IVLAACLVTG GRIADLLGRK RMFIYGVALF TAASVLCAAA GSVEQLVAFR
VLQGIGAAVL IPASLALVVE GFEVARRARG IGLWGSAAAL ASGLGPPIGG ALVEVASWRW
VFLVNLPLGV VAVVVARRGL VESRAPGRRH APDLRGASLL AIALGFVTLG LVKGSDWGWV
SAATIGSGLA GAVAMAGFVL SSHYHPAPLI DPALLRIRSF AAGNVLTVIA SAGFYGYLLT
HVLFLNYVWG YTLLQAGLAI APAALVAAVV AAVLGRVADR RGYRVIIVAG ALMWAGSLLW
YIERVGSTPN FLGAWLPGQL LQGIGVGATL PVLGSAALAG LAAGGGYATA SAVVSSARQL
GAVLGIALLV VVIGTPARGA FEPGLRRGWV LAAICFALVA MAGLFLGRVR HSAAEVVESA
PAPRGDPLTP RPTPQPEFAP SQHRSAASHE VDLLAALPLF AGLDAVALAE LRDRAEHVEL
EAGAYLFHQG EVSDCLYVLR HGRLQVIQND IIVRELGRSE VVGELGLLID APRSASIRAV
RDSTLVRLGK ADFNKIADSG VFEALVQVLA TRLHQAPPPA VPYPPAPEVV VAVVGIDTPA
PVSMVATELV AALSQRLRAV NPGRVDRDGL ENAELAADKV VLQAAADDAG WRDFCLRVAD
RVVLVVADPT PPSAPLPARA VGADLVLAGP HAQREHRRRW EELITPRSMH AIRPGHAAAD
LRPLAARIAG RSIGLVLGSG GARGFAHLGV LEELEAAGLT VDRFAGTSMG AMIAALAATG
MNATAIDAYV YEYFLRNSLI SDYTVPSKGL IRGRRTLAAL QSGFGGLLVE ELPKQFRCVS
VDLLARRAVV HRRGRLADVI GCSMRVPGLY APQIYDGTLH VDGAVLDSLP VAALASDEGP
VIAVRIGADS ADDLTSSTPQ VPSIVDTLMR TMTIGSGMAS AAELAHADLA IRPDVSEVGF
LEFHQIDRAR EAGRIAAREV MPQIMALAHR
//
