ID A0A0J1BNB8_9SPHI Unreviewed; 896 AA.
AC A0A0J1BNB8;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=AB669_03435 {ECO:0000313|EMBL:KLT66988.1};
OS Pedobacter sp. BMA.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=1663685 {ECO:0000313|EMBL:KLT66988.1, ECO:0000313|Proteomes:UP000036014};
RN [1] {ECO:0000313|EMBL:KLT66988.1, ECO:0000313|Proteomes:UP000036014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BMA {ECO:0000313|EMBL:KLT66988.1,
RC ECO:0000313|Proteomes:UP000036014};
RA Anderson B.M., Pipes S.E., Miller J.R., Newman J.D.;
RT "Pedobacter sp. BMA.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KLT66988.1}.
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DR EMBL; LECU01000002; KLT66988.1; -; Genomic_DNA.
DR RefSeq; WP_047797905.1; NZ_LECU01000002.1.
DR AlphaFoldDB; A0A0J1BNB8; -.
DR STRING; 1663685.AB669_03435; -.
DR PATRIC; fig|1663685.3.peg.723; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000036014; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04865; LigD_Pol_like_2; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014143; NHEJ_ligase_prk.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KLT66988.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000036014};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 336..459
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 101318 MW; BB2BEACC903A404A CRC64;
MSLEKYKTKR DFSKTSEPEA GKSKDKNKLL FVIQKHDASR LHYDFRLEMD GVLKSWAVPK
GPSTDPKNKR LAMMVEDHPF DYRNFEGLIP KGEYGGGTVI VWDEGTYEPI EAIKGKKAQE
KHLLKQLAEG SVKIKLHGKK LEGEFALVKT HGMGENGWLL IKHKDDYASV KDITKKGESV
LSGKTIETMA KSSEKVWKDG KEQEIKEKPA EPRKSAAKKK PASINKDDLN TKKILKDAPK
SSIPTGIKPM LATLVDAPFD DDEWQYEVKW DGYRALSFIE KGKVSLLSRN NKSFDDKFYP
IHDLLAKWEI NAVIDGEILV LKKNGVSDFG ALQNWRSEAD GELVYYVFDL LWYEGKNLMG
LTLIERQAIL KDILPLDSDQ IRLGQVFKAS GVEFFAAAEK MGLEGIIAKK TSSTYVADRR
SKDWLKIKVS KRQEVVIAGY TTNADSPKTF SSLLLGVYDQ KNLSYVGKVG TGFSDADQKE
MMKLFKPLET EKLPFSELPD VNKPSRFRPN PPNAKATWLK PQLVCEVAFT EVTEDGVFRH
PSFKGMRTDK AAKDVVREKE VPVGQIMNEV DAKHDSAIKP PKEKGGKTLL NPKDETQVRK
VKGHELKFTH LSKVYWPGDK VTKRDMFNYY YQVSDYILPY LKDRPQSLNR FPSGIHGKSF
YQKDVKGKAP DWAKTFPYEN GEGEKKEYLV GTDEASLLWM ASLGCIEMNP WFSRIQSPDH
PDYCVIDLDP DKHTFDQVIT AALETKKILD AIEVPGFCKT SGSTGMHIYI PLDAKYTYEQ
SQMFAKIIVN LVHQQIPSFT SLERMISARK GKMYLDFLQN RPGATIAGPY SLRPKEGATV
SMPLHWDEVK PGLKMKDFNI VNTLERLKAE GDLFKGVLGK GIDLKKAINK AKTVFG
//
