ID A0A0J6WXF9_9FIRM Unreviewed; 300 AA.
AC A0A0J6WXF9;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:KMO87314.1};
GN ORFNames=AB840_03690 {ECO:0000313|EMBL:KMO87314.1};
OS Megasphaera cerevisiae DSM 20462.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=1122219 {ECO:0000313|EMBL:KMO87314.1, ECO:0000313|Proteomes:UP000036503};
RN [1] {ECO:0000313|EMBL:KMO87314.1, ECO:0000313|Proteomes:UP000036503}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20462 {ECO:0000313|EMBL:KMO87314.1,
RC ECO:0000313|Proteomes:UP000036503};
RA Kutumbaka K., Pasmowitz J., Mategko J., Reyes D., Friedrich A., Han S.,
RA Martens-Habbena W., Neal-McKinney J., Janagama H.K., Nadala C.,
RA Samadpour M.;
RT "Draft genome sequence of beer spoilage bacterium Megasphaera cerevisiae
RT type strain 20462.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMO87314.1}.
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DR EMBL; LEKT01000007; KMO87314.1; -; Genomic_DNA.
DR RefSeq; WP_048513472.1; NZ_LEKT01000007.1.
DR AlphaFoldDB; A0A0J6WXF9; -.
DR STRING; 39029.BSR42_01780; -.
DR PATRIC; fig|1122219.3.peg.2840; -.
DR InParanoid; A0A0J6WXF9; -.
DR OrthoDB; 9784013at2; -.
DR Proteomes; UP000036503; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:KMO87314.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000036503}.
FT DOMAIN 4..270
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 300 AA; 32872 MW; 461000F80A02AB4E CRC64;
MKKVEIYEVG PRDGFQNIKE YIPLETKLEI VDGLVQAGIR HIEVTSFVSP KAIPQLKDSL
ELSRRCLDQY PDVDFIALIP NLRGAQAAVQ AGIKRIAYVV SLSASHNKAN INRTHEQSYA
ALQEIMTAYP QLDIILDLAT TFGCPFEGKV PASRVVEFLE EYITLGVKQV CLCDTIGIAN
PAQVRDSIAA LRTAYPQLEL QVHIHDTRNM GAACTLAAIE AGVTKIQSTL GGLGGCPFAP
GASGNLATED MIYMLNEMGY DTNINFERIL NLAKEEVKRI PAGVYSGHHI HVDATSQCFR
//
