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Database: UniProt
Entry: A0A0J6WYQ6_9FIRM
LinkDB: A0A0J6WYQ6_9FIRM
Original site: A0A0J6WYQ6_9FIRM 
ID   A0A0J6WYQ6_9FIRM        Unreviewed;       497 AA.
AC   A0A0J6WYQ6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AB840_01305 {ECO:0000313|EMBL:KMO87789.1};
OS   Megasphaera cerevisiae DSM 20462.
OC   Bacteria; Firmicutes; Negativicutes; Veillonellales; Veillonellaceae;
OC   Megasphaera.
OX   NCBI_TaxID=1122219 {ECO:0000313|EMBL:KMO87789.1, ECO:0000313|Proteomes:UP000036503};
RN   [1] {ECO:0000313|EMBL:KMO87789.1, ECO:0000313|Proteomes:UP000036503}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20462 {ECO:0000313|EMBL:KMO87789.1,
RC   ECO:0000313|Proteomes:UP000036503};
RA   Kutumbaka K., Pasmowitz J., Mategko J., Reyes D., Friedrich A.,
RA   Han S., Martens-Habbena W., Neal-McKinney J., Janagama H.K.,
RA   Nadala C., Samadpour M.;
RT   "Draft genome sequence of beer spoilage bacterium Megasphaera
RT   cerevisiae type strain 20462.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KMO87789.1}.
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DR   EMBL; LEKT01000002; KMO87789.1; -; Genomic_DNA.
DR   RefSeq; WP_072061708.1; NZ_LEKT01000002.1.
DR   EnsemblBacteria; KMO87789; KMO87789; AB840_01305.
DR   PATRIC; fig|1122219.3.peg.296; -.
DR   Proteomes; UP000036503; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000036503};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036503}.
FT   NP_BIND     195    202       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   497 AA;  57029 MW;  2FF2589E65A16034 CRC64;
     MEQFDLTTLW MGMLTELKQS LPPQIYDNWF ESALIPYSYE NNELTLDTAS KFVCAYISKR
     YTSLLETIAQ NVTGLPTRVT LINSVENTPQ EPPSAIYETQ SLPEPAAHNQ EWVQQELPSM
     EIETVKKKPD TALPEIREAA SIISPAPDTR LENNLIQNYT FETFIVGNSN RIAHAASLAI
     AEAPAKKYNP FYIYGSSGLG KTHLMHAIGH RILHNFPQMR LRCITSEDFV NEFIQCIQDK
     STESFRQRYR NIDILLVDDI QFLGRGDKES SKEEFFHTFN KLYQDQKQMV FTSDRPPQDI
     KRLEDRLRSR FQSGMVTSID PPDLETRTAI LKIWAQKENV SIENNAIDYI ASNVSENIRD
     LNGAFISVLL LASAEKSPIT LNLTQRAIKY ITDEKDEKKY ITIDEITKSV CEFYNVNYKE
     LMGKKKTKDI ALPRQIAMYL CRELTGNTYP HIGTAFNGRD HTTVMHACTK VMKTMEKDIR
     FKESIEKLKI KITGVDN
//
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