ID   A0A0J6Y2L6_COCIT        Unreviewed;       766 AA.
AC   A0A0J6Y2L6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN   ORFNames=CIRG_02094 {ECO:0000313|EMBL:KMP01955.1};
OS   Coccidioides immitis RMSCC 2394.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP01955.1, ECO:0000313|Proteomes:UP000054565};
RN   [1] {ECO:0000313|Proteomes:UP000054565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC       {ECO:0000256|ARBA:ARBA00043957}.
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DR   EMBL; DS028093; KMP01955.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J6Y2L6; -.
DR   STRING; 404692.A0A0J6Y2L6; -.
DR   Proteomes; UP000054565; Unassembled WGS sequence.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   CDD; cd06147; Rrp6p_like_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   InterPro; IPR049559; Rrp6p-like_exo.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF08066; PMC2NT; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   3: Inferred from homology;
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT   DOMAIN          450..530
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          627..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..766
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   766 AA;  84393 MW;  DF539E37F7EE55DD CRC64;
     MDLATEFSPF QEKLTAALVQ ATKTTSQLLA QDIAFQRSVN PSLSNSLDEQ SARFLGLTNS
     ILRFATSGSD LNAPSLEDED GVDENWRGVV DVIDELLEKA DACLDEFTGI IKKLGPSQDE
     RGQELNKRAS RAQFPGAHNF ASSKIPKPQL SFKTRPNNHA SSPFRPILRQ KPHALIPLPP
     VAEQTSTNGD VEQSEHPYAH EIRDCHYPAS TYSSSTPQLY KPFESTTATF VNTIEGVKVM
     LEELKSAKEI AVDLEHHDAH SYHGLVCLMQ ISTREKDWIV DTLLPWREEL QILNEVFADP
     RILKVLHGSS MDVIWLQRDL GLYLVGLFDT YHASVALNYP KKSLKFLLDK FVNLEAEKQY
     QTADWRLRPL LPGMFDYARS DTHYLLYIYD NLRNELIEKS TPDTNLIDYV QDKSKEEALQ
     RYERPVYDAE TGQGSGGWYD VLSRSPSLLK REQLAVFKAV HRWRDQTART DDEGVQSVLS
     KRALFAIAHG MPSDQAALLK LAIPVSPSLR KRLSELLKVI KDAKASGVDG PELHEVLASG
     PATLVSGVKA MEPSPAGAEK EASMASSAKA VRALVSQFWG TTLEQTESTN ASIYAPLAAA
     DALALSLPLP SMPINISEEA HGIEDEAMET SATPPAPKFE KEDDRTSGLA PDQIFTVKQF
     GAGPKRKAAP PDTELSPAPS PVSNSPHPDV AGPGSKKQKT SAAEDVVAPF DYAKAESVLQ
     AGRAEDVRNL PRKPQFNPYA KALDAPQALR KSKKDMGGGK SFTFQK
//