ID A0A0J6YBV2_COCIT Unreviewed; 831 AA.
AC A0A0J6YBV2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Elongation factor 2 {ECO:0000256|ARBA:ARBA00017891};
GN ORFNames=CIRG_04907 {ECO:0000313|EMBL:KMP05225.1};
OS Coccidioides immitis RMSCC 2394.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP05225.1, ECO:0000313|Proteomes:UP000054565};
RN [1] {ECO:0000313|Proteomes:UP000054565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; DS028095; KMP05225.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J6YBV2; -.
DR STRING; 404692.A0A0J6YBV2; -.
DR Proteomes; UP000054565; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR CDD; cd03700; EF2_snRNP_like_II; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF10; ELONGATION FACTOR 2; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:KMP05225.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 5..242
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 831 AA; 92016 MW; EDC6420D7F19F27E CRC64;
MDRPANIRNM SVIAHVDHGK STLTDSMVQR AGIISAAKAG EARFTDTRQD EQDRCITIKS
TAISLYAHLS DPEDIKDIPQ KVDGNEFLIN LIDSPGHVDF SSEVTAALRV TDGALVVVDC
VSGVCVQTET VLRQALSERI KPVCIINKVD RALLELQVSK EDLYQSFART IESVNVIIAT
YFDPALGDVQ VYPYKGTVAF GSGLHGWAFT VRQFAVKYAK KFGVDRNKMM ERLWGDNYFN
PKTKKWTKVG EHEGKQLERA FNQFILDPIF KIFNAITHSK KDEISVLLEK LEIKLSSDEK
DLEGKPLLKV VMKKFLPAAD ALLEMMVLHL PSPVTAQKYR AETLYEGPPD DEVCIGIRDC
DPKAPLMLYV SKMVPTSDKG RFYAFGRVFA GTVRSGLKVR IQGPNYTPGK KEDLHIKAIQ
RTILMMGRFI EPIEDVPAGN IVGLVGVDQF LLKSGTLTTC ETAHNLKVMK FSVSPVVQRS
VEVKNANDLP KLVEGLKRLS KSDPCVLTYI SESGEHVIAG AGELHLEICL KDLEEDHAGV
PLRVSDPVVS YRETVGAESS ITALSKSPNK HNRLYVKAEP LAEEVSNAIE AGKISPRDDF
KARARVLADE FGWDVTDARK IWCFGPDTTG ANLVVDQTKA VQYLNEIKDS VVSGFQWASR
EGPIAEEPMR SVRFNILDVT LHADAIHRGG GQIIPTARRV IYAATLLAEP GILEPVFLVE
IQVPEQAMGG IYGVLTRRRG HVFSEEQRPG TPLFTVKAYL PVNESFGFSA DLRSATSGQA
FPQSVFDHWQ ILPGGSPLDP TTKPGQIVQE MRKRKGIKEV VPGVENYYDK L
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