ID A0A0J6YQ09_COCIT Unreviewed; 903 AA.
AC A0A0J6YQ09;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=DUF221 family protein {ECO:0000313|EMBL:KMP09314.1};
GN ORFNames=CIRG_09484 {ECO:0000313|EMBL:KMP09314.1};
OS Coccidioides immitis RMSCC 2394.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=404692 {ECO:0000313|EMBL:KMP09314.1, ECO:0000313|Proteomes:UP000054565};
RN [1] {ECO:0000313|Proteomes:UP000054565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 2394 {ECO:0000313|Proteomes:UP000054565};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; DS028099; KMP09314.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J6YQ09; -.
DR Proteomes; UP000054565; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF53; DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 54..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..205
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 228..420
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 432..705
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 805..895
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 299..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 101359 MW; 51DB42C79AD032E0 CRC64;
MERVFPRFYT GLELFRRDFL NQSNDPNIGS ARGDSQSPGS STLSDLGVNV STSAAALLTT
FVPAFGLAVV WFGLFLVCRR TQRRFYAPKS YLGHLHDYER SPELPSGFFN WIGVFLRLPD
SHVLRHSSLD GYFFVRFLKV MSVVCLVGCV ITWPILLPIH IAGGAGNKQL DAMSFSNVKN
PQSYYAHTIV AWIFFGFVFC AITRESILYA TLRQAYLLSP LYASRISSRT VLFLAVPQSY
LCKNRLTKVF GDSVKRVWIT SDCSKLQKLV KKRDTLAYRL EGIETGYIKK AHAAHLKSSK
GDIKDPESSM ETSPIELEKG KESFPPAPNI ERPMHRHRYV FGQKVDTIDW LRSQLKEVIP
QVEELQQRHR EGQVKPVSAV FIEFGTQMEA QIAFQTLSHH HPLQMTPRFI GISPDQVIWP
ALQYSWWQRI IRKFLIQGFI AVLVIFWSIP SAFVGSISNI TYLTNLLPFL KFINDLPGIV
KGAISGVLPT VALAILMSLA PIILRWCARQ SGLPSTARVE LFTQNAHFVF QVVQVFLVTT
LTSAASAATS QIIKDPLSAK DLLAENLPKA SNFYISYFLF QGLILSSGAV MQVVTFLVFK
LLRVLFDRTP RNLYQRWASL TGLSWGTVFP VFTNMVVIAI TYSCIAPIIL GFSSLGLYLV
YQAYRYNLLF VYDSTVDTKG LIYPRALKQV LTGIYLAEIC LIGLFAIKGA IGPLILMGIF
AIVTAVAHIS LNDALSPLLS ALPRTLDNED DVEEEIIGTG SEGCSSSSIN DPEKGIAQAT
VTHTELIGRR ARLRKKFLKF TTWLLHPSTY ADYASLRKKV RQDPGITYGQ EVDDNAYYPP
SVTSPTPLLW VPRDARGVSR QEVALTRTVI PITDEGAHLD EKNKVVWDKI GMKPPIWQEK
IFY
//
