ID A0A0J7K6T0_LASNI Unreviewed; 1072 AA.
AC A0A0J7K6T0;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Fatty acid synthase {ECO:0000256|ARBA:ARBA00018769};
DE EC=2.3.1.85 {ECO:0000256|ARBA:ARBA00012873};
GN ORFNames=RF55_15198 {ECO:0000313|EMBL:KMQ85969.1};
OS Lasius niger (Black garden ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Lasius; Lasius.
OX NCBI_TaxID=67767 {ECO:0000313|EMBL:KMQ85969.1, ECO:0000313|Proteomes:UP000036403};
RN [1] {ECO:0000313|EMBL:KMQ85969.1, ECO:0000313|Proteomes:UP000036403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole {ECO:0000313|EMBL:KMQ85969.1};
RA Konorov E.A., Nikitin M.A., Kirill M.V., Chang P.;
RT "Lasius niger genome sequencing.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMQ85969.1}.
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DR EMBL; LBMM01012829; KMQ85969.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J7K6T0; -.
DR STRING; 67767.A0A0J7K6T0; -.
DR PaxDb; 67767-A0A0J7K6T0; -.
DR OrthoDB; 3303359at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000036403; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF7; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000036403}.
FT DOMAIN 1..268
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 1072 AA; 118610 MW; C410D08EAD47CEE0 CRC64;
MFANRISYAF NLNGPSFSVD TACSSALTAM HQAVVAIHAG ECDAAIIGGL NLVLDPANSL
HFHRLNMLSK DGKCKAFDIT ADGYTRAEAV VAIYLQRAKD ARRVYATVMN TAINTDGYKP
EGITYPSGNI QYQMLQKVYS EVGINPEDVV YVEAHGSGTK AGDPEELNAI ERQFCKNRRT
PLQIGSVKSN MGHAEPASGL CSIAKVLIAM EAGVIPANLH FAIPNPKIPA LSEGRIRVID
KATPWNGGIV GINSFGAGGA NAHVILRSNS KAKMPSVPDT VEPLLPKLVA VSGRTKEAVQ
VLLDKANEHR QDDEFLSLLH TVHSDNISGH NFRGYEILAY DGTREIVETN YDEKRPIWFV
FSGMNTQWAG MGRELLGIET CQRSLQRCAD VLKSHDVDLM NIIVNGTDET YENVMIASVS
IVAIQIAFVD MLTSIDIRPD GIIGHSLGEL SCSYADGAFT LEQTILAAYY KGKSILDSDL
EPGAMAVINL NWEEARKMCP PDITPACHNS ADSVTISGTS VSVKKFVEEL KSKDILVKII
NCSGVPFHSK YIVPAESKYR ASLDAIIPKP KQRSARWISS SVPETAWDSP LAQFSSSEYH
VNNMLAPVLF QEAIAHIPEN AITIEIAPHC LLQAALRISL PSTVTNVSLQ KKNYSNNLVF
LLSNVGKMYM AGAQPDISKL YPPISFPVGR GTPMIGSLIK WDHSAMWEVP DFKQKPKESG
EYVVEVNLSK ETDAYLAGHK IDGRFIFPGA GFVVMVWKIF AKLRDTDFER LPVVFENVWF
QRITFVSEKK TIKFSISLLE GKGDFEVREG DAVVVSGNIR AAETVETDQL DLQPLPMPPT
GLLLNTEDVY KELRLRGYEY NGTFKGIKSC DSSITVGELR WFNEWSSYMD TMFQFKLLSI
DRRLVYGSKV RYAVIDPVLH KRLVDELPKD AGLPVYHYKN VEIVKSGGLE FRGMKPTTPQ
RQQIQIKPKY ERYVFVPYEN PRSLVLKDPM REKLHALTVL LQIACENVMT SRIKAVEVAG
FRTARSLLAP LVLDILNGEP LVTVSTRYRI LMNVVVTSGS GQKSPINSFD IQ
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