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Database: UniProt
Entry: A0A0J8QM35_COCIT
LinkDB: A0A0J8QM35_COCIT
Original site: A0A0J8QM35_COCIT 
ID   A0A0J8QM35_COCIT        Unreviewed;       258 AA.
AC   A0A0J8QM35;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Kinetochore protein SPC25 {ECO:0000256|RuleBase:RU367150};
GN   ORFNames=CISG_03644 {ECO:0000313|EMBL:KMU73511.1};
OS   Coccidioides immitis RMSCC 3703.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU73511.1, ECO:0000313|Proteomes:UP000054559};
RN   [1] {ECO:0000313|Proteomes:UP000054559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000256|RuleBase:RU367150}.
CC   -!- SUBUNIT: Component of the NDC80 complex.
CC       {ECO:0000256|RuleBase:RU367150}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367150}.
CC       Chromosome, centromere, kinetochore {ECO:0000256|RuleBase:RU367150}.
CC   -!- SIMILARITY: Belongs to the SPC25 family.
CC       {ECO:0000256|ARBA:ARBA00006379, ECO:0000256|RuleBase:RU367150}.
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DR   EMBL; DS268130; KMU73511.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8QM35; -.
DR   STRING; 454286.A0A0J8QM35; -.
DR   Proteomes; UP000054559; Unassembled WGS sequence.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR   Gene3D; 3.30.457.50; Chromosome segregation protein Spc25; 1.
DR   InterPro; IPR045143; Spc25.
DR   InterPro; IPR013255; Spc25_C.
DR   PANTHER; PTHR14281:SF0; KINETOCHORE PROTEIN SPC25; 1.
DR   PANTHER; PTHR14281; KINETOCHORE PROTEIN SPC25-RELATED; 1.
DR   Pfam; PF08234; Spindle_Spc25; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU367150};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618,
KW   ECO:0000256|RuleBase:RU367150};
KW   Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU367150};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367150};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Kinetochore {ECO:0000256|RuleBase:RU367150};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU367150};
KW   Nucleus {ECO:0000256|RuleBase:RU367150};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054559}.
FT   DOMAIN          183..254
FT                   /note="Chromosome segregation protein Spc25 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08234"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          59..93
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          122..160
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  30277 MW;  9D15CDFE44094308 CRC64;
     MASTFDPSMS VSGMRPPLTS ADAPSMADQL PVLNFGFDDL RARMAQFTAR FDAFIERGRK
     QVLEEKNQFR VNLAELQEDR RMKQKDIEIF NLKAQTHAQT LQKEAVEAAE MHEAIATVTQ
     ERDARQATRD RLKQQIEETQ KAINQRLEAQ RAHARQLEAQ SRLNTPELEF WQDYLCLRIE
     GAGRDDRLKI VYTHLLEKDW EREAWFELGT ASRDYEVFHC RPKLERTVIE RELDIVNEDR
     DFGAFLKRMR KLFVATMK
//
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