ID   A0A0J8QMS6_COCIT        Unreviewed;       718 AA.
AC   A0A0J8QMS6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   13-SEP-2023, entry version 34.
DE   SubName: Full=Thimet oligopeptidase {ECO:0000313|EMBL:KMU73771.1};
GN   ORFNames=CISG_03821 {ECO:0000313|EMBL:KMU73771.1};
OS   Coccidioides immitis RMSCC 3703.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU73771.1, ECO:0000313|Proteomes:UP000054559};
RN   [1] {ECO:0000313|Proteomes:UP000054559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU003435};
CC       Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR   EMBL; DS268131; KMU73771.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8QMS6; -.
DR   STRING; 454286.A0A0J8QMS6; -.
DR   Proteomes; UP000054559; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06455; M3A_TOP; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR024080; Neurolysin/TOP_N.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR   PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003435};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU003435};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054559};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT   DOMAIN          221..716
FT                   /note="Peptidase M3A/M3B catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01432"
SQ   SEQUENCE   718 AA;  82108 MW;  EA7D2A4CDF3C911D CRC64;
     MAPSHLKSPP QAPPLFTGTP SSIVDDTKRL IEQSRKVQDA VAKNVSHEAA DFAKVLLPLA
     HDENSMALES HILGFYQAVS TDSKLRDAST EAEKLMDDFA IESAMREDLF KLVDAVLKKG
     EKLEPESQRL LEKEHKDYIR NGLGLPAGPK RDRFKEIKKR LSQIAIEFQK NLNEEKGGVW
     LTREELHGVP EDVVSGLKKG EGENEGKLFL TFKYPDLFPL TKYATNADVR KRVMIANENK
     CNQNVPLFKE AIILRDEAAR LLGYPNHATF RIEDKMAKTP ETVDKFLGDL RARLKDGGQK
     EIEKLKELKA KDLKARTPSQ EADGHYFLWD HRFYDRMMLE KDYQLDHQLI AEFFPLQTTI
     RGMLKIFEDL FGLVFVEIEG EERSKLSETG KGDDIVWHED VQVFSVWDDE GEGSGFVGYL
     YLDLFPREGK YGHAANFNLQ PGFIDKDGKR RYPATALVCN FSKSTPKKPS LLKHDEVVTL
     FHELGHGIHD LVSKTTYSRF HGTNTVRDFV EAPSQMLENW CWTPSQLKSL SKHFSYLSPE
     YLEAWKEQAG DKPRPSEQIP DELIENLIKT KHVNDALFNL RQLHFGIFDM AVHEPVDHDA
     IQKLDVSEKY NSLRKEITNF EGPEVLGLGY NWGHGQATFG HLIGGYDAGY YGYLSSQVYS
     TDMFYSVFKD EPMNKKEGRR YRYTVLEKGG SQDEMETLKE FLGREPKPDA FYKELGLA
//