ID   A0A0J8QPH5_COCIT        Unreviewed;       632 AA.
AC   A0A0J8QPH5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Transcriptional repressor rco-1 {ECO:0000313|EMBL:KMU73218.1};
GN   ORFNames=CISG_03478 {ECO:0000313|EMBL:KMU73218.1};
OS   Coccidioides immitis RMSCC 3703.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU73218.1, ECO:0000313|Proteomes:UP000054559};
RN   [1] {ECO:0000313|Proteomes:UP000054559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the WD repeat PWP2 family.
CC       {ECO:0000256|ARBA:ARBA00010226}.
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DR   EMBL; DS268129; KMU73218.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8QPH5; -.
DR   STRING; 454286.A0A0J8QPH5; -.
DR   Proteomes; UP000054559; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProt.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR027145; PWP2.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR007148; SSU_processome_Utp12.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19858:SF0; PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG-RELATED; 1.
DR   PANTHER; PTHR19858; WD40 REPEAT PROTEIN; 1.
DR   Pfam; PF04003; Utp12; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054559};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          168..209
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          210..251
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          296..337
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          520..581
FT                   /note="Small-subunit processome Utp12"
FT                   /evidence="ECO:0000259|Pfam:PF04003"
FT   REGION          597..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..626
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  69149 MW;  C517C5AEB07CBA74 CRC64;
     MKLPAVLLTH YSPAINPIPF HSSHRSNIAR IDLSPNGKLL LSIYTVSKDG ALFRWQYGDK
     PGEPESTSES PILHWRITKK DYFMQQNAKL TCSAFHPKTN LLVVGFSNGI FALYELPEFN
     QLHLLSVSQS NIDYVTVNNS GEWLALGSAK LGQLLVWEWQ SESYILKQQG HLNSMNSLVY
     SPDGQKIITA ADDGKIKVWD INSGFCVVTF TEHTAAVTAC EFTKQGNVLF TASLDGSVRA
     WDLIRYRNFR TFTAPSRQQF SSLAVDPSGE VVCAGSLDSF DIHVWSVQTG QLLDRLAGHE
     GPVSSLSFAA DGSHLVSGSW DRTVRLWNIF ARSQTNAIQQ AGIDGRRDIS GGRKITDRRT
     AANAAGTKTF TTITYSADGS CLLAAGNSKY ICLYDVGTGS LVKKFTVSVN TSIDGTMEFL
     NSKNMTEAGP RALIDETGEA SDLEDRIDRT LPGAKRGDAG ARNTRPEIRV TSARFSPTGR
     SFCASSTEGL LVYSLDTDLV FDPLQILTFP SLQIASSPLS QRQKFNLLWI RALLSIHGRY
     IKDNSGSFAT ELRAVQRAVD GIRDDLKRVV DKNMYALDYL LEGPAISTSN SADAVQRTTN
     GARKAADGDD IVTMDDAGKG SDGEGEWMGI ED
//