ID A0A0J8QS45_COCIT Unreviewed; 782 AA.
AC A0A0J8QS45;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE SubName: Full=Magnesium transporter ALR2 {ECO:0000313|EMBL:KMU75549.1};
GN ORFNames=CISG_04952 {ECO:0000313|EMBL:KMU75549.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU75549.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
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DR EMBL; DS268141; KMU75549.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8QS45; -.
DR STRING; 454286.A0A0J8QS45; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd12829; Alr1p-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR PANTHER; PTHR21535:SF51; MANGANESE RESISTANCE PROTEIN MNR2; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 754..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..68
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 88766 MW; 5684C426A19333F3 CRC64;
MSNTNIPASP TARGSSPNPG RDVQRAYQGS PHRVSPFPET QIGPQGASNR HGKKRKHRHH
KRRRHRRPSF APATVETPPA GSPSREAEGI PEEGETAAPT DTRRASFYRL GQLGGATLSD
TSLDSEALLD HRYESCTDQG PYPNQPMMRT RRESRLAQSS RPEYPPLSSL ASPDNRSRPS
AARLGVKTSD ESEPESDEAD DRTPLIRPTS LHNTNFVRYG TDARDIPRPS RRSSVARNLR
EAGVCPPFRE MWSSIWKAPT GLIRLGLLHH RLRFHLSDVG PLLFPLKKTR VYGNATTTEK
KSVASLSVLE EWSREEKEER TEGIRAKKIS EPVLIGGRLR TRNAPWRREE EEAPYRFTYF
NEEFQSTIHS QTISELVQPG QTFKDLFFPE PPELESGDEE EEDEFRPLTL NGTRTNSLSM
PGYNGRSDRD SAVADSREVS PNHAPGSSPT QKEKRYGPRP TFWLDVLCPT DAEMRIIAKA
FGIHALTAED IMMQEAREKV ELFRHYYFIN YRTFEQDVNS ENFLEPVNMY VIVFREGLLS
FHFSQTPHPA NVRRRIRQLK DYLILNSDWI SYAIIDDITD VFGPLIHSIE EEVDDIDDTI
LRMHSDSKDP NDTAPPESAV SGSDMLRRVG ECRKKVMGLY RLLGNKADVI KGFAKRCNEQ
WEVAPKSEIG LYLGDIQDHI LTMTGNLTHY ETLLSRAHSN YLAQINIRMN ERQEQTADVL
GKLTVLGTIV LPMNIICGMW GMNVKVPGQD VENLHWFLSI TAGLVIFAFV CFYVAKRVYR
IV
//
