ID A0A0J8QTE5_COCIT Unreviewed; 1037 AA.
AC A0A0J8QTE5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN ORFNames=CISG_04250 {ECO:0000313|EMBL:KMU74543.1};
OS Coccidioides immitis RMSCC 3703.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU74543.1, ECO:0000313|Proteomes:UP000054559};
RN [1] {ECO:0000313|Proteomes:UP000054559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; DS268136; KMU74543.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8QTE5; -.
DR STRING; 454286.A0A0J8QTE5; -.
DR Proteomes; UP000054559; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR35859:SF4; MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED; 1.
DR PANTHER; PTHR35859; NONSELECTIVE CATION CHANNEL PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054559};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 326..537
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 11..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..813
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 116360 MW; C437D5A1C60867FD CRC64;
MSAPSPIAAR RMMFHGPLRA PGQSNQPAPN DEEYGDDGHG VDCETNDGHD TQDTTPLLPI
FSAPHLDSLP VYHLTYDLCL LVASRCETTL TWEQLRSPQV SQFLLKPILQ AIHTAHFSRA
TLYSLMANCL QFRKEADIKP GISGASHTRA MVCELLAIKL LKEYSTRELI DALSYDFHPL
QGQTPPSTTS TTAHETGRYP HSRSQRHLKG VRISCLEVAI RAQAKRFLAH PLVVQQLEAI
WAGTIVFYSA ADHLHRLPLR NATRTQYGSL GASVDPANGA YTDSTSFISR RSASLYDPQD
ASLFKLSRLR VPRYRQVLST CSFAVLLCLF LTVIQRRSFL LTTLELVFWF WSAGYMLDEI
VGFNEQGFSL YLMSFWNTFD VGILFLLFCY YCLRLYSVLL LDHTVAILAY DVLAATAVLL
VPRLFSVLDH YRYFSQLLIA FRMMAVDLFA VLILIIIACS GFFVAFTFSF GHGDSPSSVI
YALFQMIMGF TPAAWQLWDR YNPLGKAILI LFLFICHFLV VTILITVLTN SFMAIVQNAN
EENQSYLPIY LYERIALRSA VFEPTDLVDG PLRPSQSKNW VNNGNKGHDL FALGNTFRLR
EPSIATHQKD EALEQVFRRP FRQTAHRVRQ DTRAQHKSNA IVSDWMRDIG PGGIAEPPDE
EDQAVLERLE QRRILCFPGA RRRLKHSLRD PTITTRSVAS DPEDFVNSGK IRPKAPAVER
GFGHPLRKQL TQQTDMEGDD ELSSDHQQDD EVSSLRQRTT TIGSRIQDEQ EDLFNLTNGP
SSNSFKGSSR PSTAKRLSRR NSPNRKPNTP RRKHSRNLSS ATVLLNPLRS WTTGEVNPMP
SGKPALRRAF QRSTPPTPSR SPKEKTAAHT GPRPIHPSKP EAKSVPNLNG VLLSGDFLKL
NRGRSSIAIG LGSDLGDNKA VGGGFVGGIP ASFATQMAYA TGDLQRNRSN TDHRDTLNRL
VLARMKTLEE SFRDVIREVK DLRREQIYPP DIRGNMASKA NIPTSKRQYI EYHSEDGGNN
TDLIFDDSSS ELKASSV
//
