ID   A0A0J8QXY4_COCIT        Unreviewed;       449 AA.
AC   A0A0J8QXY4;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Monooxygenase {ECO:0000313|EMBL:KMU77326.1};
GN   ORFNames=CISG_06367 {ECO:0000313|EMBL:KMU77326.1};
OS   Coccidioides immitis RMSCC 3703.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=454286 {ECO:0000313|EMBL:KMU77326.1, ECO:0000313|Proteomes:UP000054559};
RN   [1] {ECO:0000313|Proteomes:UP000054559}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 3703 {ECO:0000313|Proteomes:UP000054559};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the paxM FAD-dependent monooxygenase family.
CC       {ECO:0000256|ARBA:ARBA00007992}.
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DR   EMBL; DS268154; KMU77326.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0J8QXY4; -.
DR   STRING; 454286.A0A0J8QXY4; -.
DR   Proteomes; UP000054559; Unassembled WGS sequence.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR47356; FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED; 1.
DR   PANTHER; PTHR47356:SF3; FAD-DEPENDENT MONOOXYGENASE SRDH; 1.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   PRINTS; PR00420; RNGMNOXGNASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Monooxygenase {ECO:0000313|EMBL:KMU77326.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054559}.
FT   DOMAIN          16..351
FT                   /note="FAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01494"
SQ   SEQUENCE   449 AA;  49611 MW;  3EFAD2861828509F CRC64;
     MRHPSVDHPI SETPFKVIVV GAGVAGLTLA HCLEKANIDY VVLDKGIVAP PFGTTITMQP
     HGCRILDQLG CLDAVLSQCS TMKGCSCRTS TGKVYAENRF FEVIQQIVAK MCSSGYSTCT
     LDRRVFLRTL YNQLRDKSKV LERCRVENII EETGIVKVLL ADGTEHVGNL VVGADGVHSK
     VRELMWDKAN RAIPGSISAA EKRSMATTYN ALIAMCPPVP GLSKHDMEIT SGNGFSFLLL
     CQPTFITYIA HCKLPEAKRY RWPNRGKYTE EEMEALASKL ADCPVTETVL FGELWRSRTK
     GQLISLEEGV LKHWFFGRIV LAGDAIHKIT PNSALGGCTA MESVVSIANA IHGLVHAHPN
     KEPSDVEIRD ALQHYQDSRL DRVKGIVEFG AKMTRLQAYD GWWNYITQRW ITPVIGLDCL
     ARDASRLFSG APKLNYVPFE GKAGKLGME
//