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Database: UniProt
Entry: A0A0J8RVY6_COCIT
LinkDB: A0A0J8RVY6_COCIT
Original site: A0A0J8RVY6_COCIT 
ID   A0A0J8RVY6_COCIT        Unreviewed;       857 AA.
AC   A0A0J8RVY6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   08-JUN-2016, entry version 7.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CIHG_06758 {ECO:0000313|EMBL:KMU88957.1};
OS   Coccidioides immitis H538.4.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides.
OX   NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU88957.1, ECO:0000313|Proteomes:UP000054563};
RN   [1] {ECO:0000313|Proteomes:UP000054563}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS017008; KMU88957.1; -; Genomic_DNA.
DR   EnsemblFungi; KMU88957; KMU88957; CIHG_06758.
DR   Proteomes; UP000054563; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054563};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    428    453       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    474    491       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    552    570       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    582    605       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    644    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    760    778       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    790    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   857 AA;  97850 MW;  02C8813F9C774A6F CRC64;
     MGPPQDTLLR SADMSLTQLY IANEIGREVV SALGEVGLVQ FRDLNADTTA FQRTFTSEIR
     RLDNVERQLR YFHAQMEKEG IEMRPSSEFA NTLAAPMASE IDELAQRSES LEQRIFSLNE
     SYEVLKKREV ELIEWRWVLR EAGSFFDRAH GHTDEIRQSL DNDEAPLLRD VEHQHPPRRQ
     GDDMHHQPSF SVMDIGFVSG VIPRDRIGAF ERILWRALRG NLYMNQSEIP QPIIDPSSNE
     EIQKNVFVIF AHGKEIIAKI RKIAESLGAS LYSVDENSEL RRDQIHEVNT RLGDVESVLR
     NTKVTLDAEL SQIARSLAAW MIIVKKEKGV YHTLNKFSYD QARKTLIAEA WCPTNSLPLI
     KATLQDVNDR AGLSVPTIVN QIRTNKTPPT YIKTNKFTEG FQTIIDAYGI SKYREVNPGL
     PTIITFPFLF AVMFGDCGHG LLMTMAAVTL ILFEKKLAKT KLDEISSMAF YGRYIMLLMG
     VFSIYTGLIY NDMFSRSLEI LPSAWEWPEV TREGQSVTAT LKGSYRYPFG LDWGWHAADN
     NLLFSNSFKM KLAILLGWSH MTYSLCLSFL NGRHFKKPIE IWGNFVPGMI FFQSIFGYLA
     FTIIFKWVVD WPARGQQPPS LLNMLIFMFL RPGSVEEQLY KGQGAVQVIL LLLAVIQVPI
     LLFLKPFYLR WEHNRARALG YRGLGEISRV SALDENEEDG RGSARHSMTS DADGIGMITQ
     DMGEEEHEEF DFGDEMIHQI IHTIEFCLNC VSHTASYLRL WALSLAHQQL SIVLWTMTLN
     NAFTSESSTV RVILTIVTFY MWFTLTVAVL CVMEGTSAML HSLRLHWVEA MSKHFMGDGI
     PFTPFSFKIL LEEDPVD
//
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