ID A0A0J8S8E6_COCIT Unreviewed; 611 AA.
AC A0A0J8S8E6;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Peroxisomal targeting signal receptor {ECO:0000256|ARBA:ARBA00014710};
DE AltName: Full=Peroxin-5 {ECO:0000256|ARBA:ARBA00032505};
GN ORFNames=CIHG_10484 {ECO:0000313|EMBL:KMU92639.1};
OS Coccidioides immitis H538.4.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=396776 {ECO:0000313|EMBL:KMU92639.1, ECO:0000313|Proteomes:UP000054563};
RN [1] {ECO:0000313|Proteomes:UP000054563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H538.4 {ECO:0000313|Proteomes:UP000054563};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBUNIT: Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting
CC translocation through the PEX13-PEX14 docking complex.
CC {ECO:0000256|ARBA:ARBA00038659}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Peroxisome matrix
CC {ECO:0000256|ARBA:ARBA00004253}.
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000256|ARBA:ARBA00005348}.
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DR EMBL; DS017113; KMU92639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J8S8E6; -.
DR STRING; 396776.A0A0J8S8E6; -.
DR VEuPathDB; FungiDB:CIHG_10484; -.
DR eggNOG; KOG1125; Eukaryota.
DR Proteomes; UP000054563; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130:SF0; GH08708P; 1.
DR PANTHER; PTHR10130; PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000313|EMBL:KMU92639.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054563};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT REPEAT 330..363
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 441..474
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 483..516
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 611 AA; 68051 MW; FA681F2BEA60FA63 CRC64;
MSFLGGAGCS AAGNPLTQFT KHVQNDTSLQ RDRLVGRSLG GLQEGMRSQS IMVGQDQMMD
EFLQQEDQIP PAATHPFSME QMRLELENFQ AGPPRTGSSG WAAEFDTVKN ARMDPAFPGP
KSQLMQGIGF SAKEFAHFSH QSSPQRTASP VTSTPAVLSS YHPQRGMGYR GVGGNYMPMM
GSSYGHMAIH QQSSAQEDKG KGRMVELDDK NWEAQFAEID AAGEKALDEE ATAAMEAELD
DLDRRMVNEE VNFENMHLGE FGEWDNFDGS LNTHSFRDPQ LGDYLFEEEN SYRLIPNPFE
EGIRMMREGD NLSLAVLAFE AAVQKDPKHV EAWTMLGSAQ AQNEKESPAI RAYEQALKLD
PSNLDARMGL AVSYTNEGYD STAYRTLEIW LSVKYPQIIN PKDITPDTEM GFTDRHLLQE
KVTDLFIRAA QLSPQGEHMD PDVQVGLGVL FYGAEEYDKA VDCFSAALAS NESGTSNQQE
QLHLLWNRLG ATLANSGRSE EAIEAYEKAL TIRPNFVRAR YNLGVSCINI GCYPEAAQHL
LGALAMHQAV DRGESFPFSE DEIADSHSTH NQSTNLYDTL RRVFNQMGRR DLSDMVVNGM
DVEVFRKEFT F
//
