ID A0A0J9UCS5_FUSO4 Unreviewed; 1029 AA.
AC A0A0J9UCS5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN ORFNames=FOXG_01995 {ECO:0000313|EMBL:KNA97158.1};
OS Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935
OS / NRRL 34936) (Fusarium vascular wilt of tomato).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=426428 {ECO:0000313|EMBL:KNA97158.1, ECO:0000313|Proteomes:UP000009097};
RN [1] {ECO:0000313|EMBL:KNA97158.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4287 {ECO:0000313|EMBL:KNA97158.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Ma L.-J., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Young S., LaButti K., DeCaprio D.,
RA Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C.,
RA Larson L., White J., O'Leary S., Kodira C., Zeng Q., Yandava C.,
RA Alvarado L., Kistler C., Shim W.-B., Kang S., Woloshuk C.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KNA97158.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4287 {ECO:0000313|EMBL:KNA97158.1};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; DS231697; KNA97158.1; -; Genomic_DNA.
DR RefSeq; XP_018235204.1; XM_018379180.1.
DR AlphaFoldDB; A0A0J9UCS5; -.
DR GeneID; 28944219; -.
DR KEGG; fox:FOXG_01995; -.
DR VEuPathDB; FungiDB:FOXG_01995; -.
DR OrthoDB; 2786490at2759; -.
DR Proteomes; UP000009097; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10812; GH38N_AMII_ScAms1_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009097}.
FT DOMAIN 502..581
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1029 AA; 117005 MW; EA011E556FC2753D CRC64;
MYNGRYSGKP HVQLSVWDAP DLSRPTFEEA TSHEFKETHT GTSFGPSWST HWFKVVLRIP
DETKDEELIE LHWDANNEGT IWTEDGVPIQ GLTGSGERIE WIIPDSFRDG EEHTIYIEMA
CNGMFGNAPN GTTTIAPPDP NRRFNLSKAD IVAINVPARK LHLDMWEIGD AARELPENSA
EQNHALSVAM KIINTFEVNN QESILKCREI AREILGPDVD SHKVYEGGKE PVVFGIGHCH
IDSCWLWPWA ETKRKVVRSW MNQCDLMDRY PESNFACSQA QQYKWLKTYY PAAYKRVKQK
VKEGQFHPIG GSWVEHDTNL PSGESLVRQF FYGQRFFEAE FGSRCRTFWL PDTFGYSSQL
PQLCRLAGMD RFLTQKLSWN NINNFPHTTF MWVSPDGSQV ICHMPPSETY TANADFGDLK
RSIANHKTMR VDSSSLLVFG KGDGGGGPTW QHFEKLRRCA GISNTIGGIP KIKMGLTVDG
YFDRLNRKAS EFPTWYGELY FELHRGTYTT QANNKYYNRK AEVMLRDIEQ LATFASIKNK
SYKYPTKDLD DMWEAVLLCQ FHDCLPGSSI EMCYDDSDKV YAEVFETGKR LLKDLYESLN
VSSEFSTCLN ESVAINTLPW HRKELVELSE TEVGVACGDG QLLNLRTFKT QEEKPAVTVM
EQSTDVYVLQ NEQLRVVVES GVITSLYDVV NDREVIEKGG EANKFVIFDD IPLYWQAWDV
EVYHLDARRK VEYGKTKIFE QKPHRVTLVT DVKISENSYI KSYTTLSAAL KGQPSRVDVR
ADVNWHEDSK FLKVEFPVNV VNTEASYETA FSITKRPTHY NTSWDMAKFE VCCHKFADLS
ENNYGVSILN DSKYGFATAG KTMRLSLLRA PKAPDANADM GRHSIRWAIL PHKGSLSSTT
VKAAYAFNNP LKPVTASKAV LESVSSAPIK LVNIDESDSL VLDTIKRGQD DEDVSRDDGL
RINKGQSIIL RVYESLGGRS RGVIETSFDV KRVTKTNILE DELEEIQKED GKIPITLRPF
EVATFKLEL
//
