ID A0A0J9UGQ0_FUSO4 Unreviewed; 1133 AA.
AC A0A0J9UGQ0;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=von Willebrand and RING finger domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=FOXG_02063 {ECO:0000313|EMBL:KNA97285.1};
OS Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935
OS / NRRL 34936) (Fusarium vascular wilt of tomato).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=426428 {ECO:0000313|EMBL:KNA97285.1, ECO:0000313|Proteomes:UP000009097};
RN [1] {ECO:0000313|EMBL:KNA97285.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4287 {ECO:0000313|EMBL:KNA97285.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Ma L.-J., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Young S., LaButti K., DeCaprio D.,
RA Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C.,
RA Larson L., White J., O'Leary S., Kodira C., Zeng Q., Yandava C.,
RA Alvarado L., Kistler C., Shim W.-B., Kang S., Woloshuk C.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KNA97285.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4287 {ECO:0000313|EMBL:KNA97285.1};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
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DR EMBL; DS231697; KNA97285.1; -; Genomic_DNA.
DR EMBL; DS231697; KNA97286.1; -; Genomic_DNA.
DR EMBL; DS231697; KNA97287.1; -; Genomic_DNA.
DR RefSeq; XP_018235331.1; XM_018379298.1.
DR RefSeq; XP_018235332.1; XM_018379299.1.
DR RefSeq; XP_018235333.1; XM_018379300.1.
DR AlphaFoldDB; A0A0J9UGQ0; -.
DR GeneID; 28944285; -.
DR VEuPathDB; FungiDB:FOXG_02063; -.
DR OrthoDB; 663280at2759; -.
DR Proteomes; UP000009097; Unassembled WGS sequence.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000009097};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 115..161
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 406..526
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 596..769
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..989
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 124140 MW; AF632C52B8CB2C6D CRC64;
MFRRLRKNQD HNTTSSQGRD DDKAIATNLR ELGLVGSRAS SRRPRTGTDS KPFTEGHSIK
AKSLRGQDSV SSAGSVRSGV SNASRRVGSI DNNVMATNAD RSRSRRERTF VGSECAVCEE
PLEHTLRGER ILQFSCSHVS HEACFYEFIR EFESQYCPTC DAPLHLDTSR GGNVIDIEKI
SNMVRSVGTD SRSAMTPTPT ATPWDNQPAR APSVESNQRR PMQQQHVGGR DSVARGSMRD
SRDAPLSDRY GPSRHARSDS EATGVASSGG YPETTQSGPA RRHDYDVQAM ETTPASPRPM
TRNPIPAPIV TVRSEFPTLN RSRQQQTLTC LVTVEVPDNN WRPDPEDLGA AAPLPPPTTN
RAEEAYGRPP SPARSAPRFY PYESTEVLEE MTDSLRNRVD NWHGLDFSRF GKLRLYGTLR
VGKDKVSWQE LECFLFAEML ICVKEKKIPQ AQQWDENGAP RKTTRCTLKG SILIKKHLNE
VSETGNIDEN ILTLSLSVAE LPQFHLRFEN RNQLKLWQQA LLDLNAVETS PVRSPEYDRG
ESETDEELEW QRSRPQRVSS VASSWGGARS TTTAPTDYTN FPRSPAMAKS VHVPIDVVVV
VPISSSMQGV KINLVRDALK FMVNTLGERD RMGLVTFGSG GGGVPIVGMT TKAWPGWSNI
LTSIKPVGQK SHRADVVEGA NVAMDLLMQR KYNNPIASIM LISDASTSDA DSVDFVVSRA
EAAKITIHSF GLGMTHKPDT MIELSTRTKA SYTYVKDWMM LRECLAGCLG SMQTLSHQNV
KLKLKLPEGS PAKFHKISGA LQITKRATGR DAEASLGDLR FGDKRDVLVQ LVILPDNTSQ
EQLPQDPWDN IVSGLEALGG PMDNDNERTL SVEEVPLIQA DLSWGDILRE GTVTHMPRPS
LLAITMLPVS GGSKKAWQNS PPIPPHPSIV QRRMELLTSD MLTRALTLVS RGQHDRAHTL
LNETRSILKG LGKGGLPPIP PPSKSTPSAP STPHPANDAS PGQSTTPDRK RSPSPPASAI
SGVNGLPSSQ LGRSRSNDGL GLGAGIDANT VAALDAELES SLEWINHPAV FSRDSRKAVL
QAIGVISSQR AFTYRTPIEG LWACRVSGVK KLTEKSREWR EDGGGEGGIT EES
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