ID A0A0J9XW25_BRUMA Unreviewed; 523 AA.
AC A0A0J9XW25;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 03-MAY-2023, entry version 41.
DE SubName: Full=Aminopeptidase ZK353.6 in chromosome III, putative {ECO:0000313|WBParaSite:Bm7455a.1};
DE SubName: Full=BMA-LAP-1, isoform b {ECO:0000313|EMBL:CDP96591.1};
GN Name=bma-lap-1 {ECO:0000313|WormBase:Bm7455b};
GN Synonyms=Bma-lap-1 {ECO:0000313|EMBL:CDP96591.1};
GN ORFNames=Bm7455 {ECO:0000313|WormBase:Bm7455b}, BM_Bm7455
GN {ECO:0000313|EMBL:CDP96591.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP96591.1};
RN [1] {ECO:0000313|EMBL:CDP96591.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP96591.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP96591.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP96591.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7455a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; LN856958; CDP96591.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J9XW25; -.
DR EnsemblMetazoa; Bm7455a.1; Bm7455a.1; WBGene00227716.
DR WBParaSite; Bm7455a.1; Bm7455a.1; WBGene00227716.
DR WormBase; Bm7455b; BM28274; WBGene00227716; Bma-lap-1.
DR OMA; MVCEQSD; -.
DR OrthoDB; 2899215at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR Gene3D; 3.40.50.10590; Zn-dependent exopeptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR041417; NPEPL1_N.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963:SF4; AMINOPEPTIDASE NPEPL1-RELATED; 1.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF18295; Pdase_M17_N2; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 362..369
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 523 AA; 56664 MW; 4C9EE65A7ABB2F8A CRC64;
MRGVLRLTSF IRHTKHFKSL TTMATLNVKQ GIDPEVQLSK DTQILLIGKK KLLKDIKFDG
NIMAKFSGFV TSKTWDSLME TLADNSSAAI PLHLNLATVI AVGDESSRHN APSNALSIFK
EVKKAGQADG IKNVSIILYA MLADIFPSVA AIARCYPLYS RFTENIISLE NVQIEIVVTD
GEKLTNRDLL FLQTLTESIR NTARLIDMPH NELNTEQFVA EATELILTLP NIQSTIIKGN
DLLAKGFGGI YHVGKASASP PIFACFSHKP QNATKTYAMV GKGIVYDTGG MQIKTKTLMP
GMKNDMGGAA ALLGSFYTLV KLGFKQNLHC LLCVADNTIS HTANRPDDII TMLSGKTVEI
TNTDAEGRLV LADGVYYAKN MLKADTIIDM ATLTGAQGLA TGKLHAAVLT NSEEWENRAC
KAGRASGDLV HPLPFCPDLH FSDLKSPVAD MRNSTFSKMQ GPGSSIAGLF IASHIDFGSG
LDWIHFDIAF PVEHGNRATG YGPALICALL ASHLDVPLLK TLQ
//