ID A0A0J9Y1X2_BRUMA Unreviewed; 684 AA.
AC A0A0J9Y1X2; A0A0R3RF32;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 13-SEP-2023, entry version 37.
DE SubName: Full=Bm7450, isoform e {ECO:0000313|EMBL:CDQ00067.1};
DE SubName: Full=TPR_REGION domain-containing protein {ECO:0000313|WBParaSite:Bm7450.1};
GN Name=Bm7450 {ECO:0000313|EMBL:CDQ00067.1};
GN ORFNames=BM_Bm7450 {ECO:0000313|EMBL:CDQ00067.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ00067.1};
RN [1] {ECO:0000313|EMBL:CDQ00067.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ00067.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ00067.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ00067.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7450.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
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DR EMBL; LN857010; CDQ00067.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0J9Y1X2; -.
DR EnsemblMetazoa; Bm7450.1; Bm7450.1; WBGene00227711.
DR WBParaSite; Bm7450.1; Bm7450.1; WBGene00227711.
DR OMA; EHEQAMN; -.
DR OrthoDB; 1215698at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR PANTHER; PTHR12558:SF9; CELL DIVISION CYCLE PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 517..550
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 551..584
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 76942 MW; 78998203300B9224 CRC64;
MVGRSAAKQR PTLTRESTSK DLTQTPMSLP TSSTSALSAP LDASSQAFLT SDGNCELSEI
DSLIQRYLAS AQYKTALFWA DKQLALCRKN GSQPSFVDMA RFIKVLAAAG EWTRLMAYCD
RHELIMKHMF FAYFYVNALY KKKLFVDILK LKLGTGDRCH DLVFSIMPHM LQLSRPKSFL
PSSEEMIALD KISEDLQVEA GLLLLLGKAY LMTQNRRAAF SCLQGAVYKD DSCIEAFELI
QKYRLYSKQR FEELIERSED KNSMVVALRN HYFSQGSKNL NSDALINEAL ITDLSILTAR
ASHLYQAGDL TGAYNITNEI LNEAGMFQDC LLIHIATLVQ LRKFENLFVL AHQLVDCQPD
NEVSWYTVGC YYYSIGQLSA AKNFFNKCTS MNCAFGEGWL AFGHALTAES EHEQAMNCYL
RASRVLEGSF EPLLYIGLEY AYANNTKLAQ DFLKDAAEIA GDNALVLHEQ GCICYMKKEW
KNAETFFTKA LLSAYNETDE HAHACDLLNR PLSEFWEPLV NNLGHVKCKL GSYDEAVKFH
QKALLMCPGK LGPNAGLAIA AGRSGDIDRA VHYFHKSLSV DPHNKVLEQG LHQLMHFLGT
HTSFLASCIR TPTLMIGSFE KFLVTKADLE GNSDEKQTQQ KALETLKRKR AKRAAQEGCE
RTMLDQRPRN LPMHDISPAD VEMT
//
