ID A0A0J9Y9Z8_BRUMA Unreviewed; 497 AA.
AC A0A0J9Y9Z8;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=BMA-EXP-2, isoform a {ECO:0000313|EMBL:CDQ05433.1};
DE SubName: Full=Cation channel family protein {ECO:0000313|WBParaSite:Bm3321a.1};
GN Name=bma-exp-2 {ECO:0000313|WormBase:Bm3321a};
GN Synonyms=Bma-exp-2 {ECO:0000313|EMBL:CDQ05433.1,
GN ECO:0000313|WBParaSite:Bm3321a.1};
GN ORFNames=Bm3321 {ECO:0000313|WormBase:Bm3321a}, BM_Bm3321
GN {ECO:0000313|EMBL:CDQ05433.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ05433.1};
RN [1] {ECO:0000313|EMBL:CDQ05433.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ05433.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ05433.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ05433.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm3321a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN856468; CDQ05433.1; -; Genomic_DNA.
DR RefSeq; XP_001894369.1; XM_001894334.1.
DR STRING; 6279.A0A0J9Y9Z8; -.
DR EnsemblMetazoa; Bm3321a.1; Bm3321a.1; WBGene00223582.
DR GeneID; 6097822; -.
DR KEGG; bmy:BM_BM3321; -.
DR WBParaSite; Bm3321a.1; Bm3321a.1; WBGene00223582.
DR CTD; 6097822; -.
DR WormBase; Bm3321a; BM07242; WBGene00223582; Bma-exp-2.
DR OMA; PPHNETI; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:EnsemblMetazoa.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18317; BTB_POZ_Kv; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF133; PROTEIN CBR-EXP-2; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..160
FT /note="Potassium channel tetramerisation-type BTB"
FT /evidence="ECO:0000259|Pfam:PF02214"
FT DOMAIN 209..467
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 497 AA; 56739 MW; E66E29C0CEB7C2F9 CRC64;
MISGAAQQHK KRLVSYRKTD AEAYTERNNA TRLDEIWGSG TDCFQAVPAD GRSDNGEPMF
LRLNIGGTSY LLLIEAILRT ETTSFLSKFI QLNHKSRLKV ADAYIAREDA YYFQRSPYAF
DAVFQYYATG VVHRPPEICP AAFLAELEFW GISYRSIGSC CADIVARDRF EEKEEEKVDN
KTFDNLMFGR VRRKMWTFLE RPGSSIQAKA FELSSTLFVA ISVMGLSFGT IPDFQVTQYL
PAHNETILLP NGTITVIEKI EEMRVEHQIF VLTERICIAF FTVEYCLRLF AAPRKFRFTL
KPLNLVDLMA IVPFYLELLL TLCGVDDKKL RDLRWAFLVV RILRVLRVIR IIKLGRFSSG
LQTFGMTLQR SQKQLQMMTI VLLTGVVFFS TMIYFLEKDE DGTPFTSIPA AYWWCIVTMT
TVGYGDAVPA TTMGKIIASA AIMCGVLVLA LPITIIVDNF IKVAQDEQQA EQQRMDHLRQ
ERRIQSILNK ETSNEDS
//
