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Database: UniProt
Entry: A0A0K0DHA8_ANGCA
LinkDB: A0A0K0DHA8_ANGCA
Original site: A0A0K0DHA8_ANGCA 
ID   A0A0K0DHA8_ANGCA        Unreviewed;       819 AA.
AC   A0A0K0DHA8;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   12-APR-2017, entry version 6.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Angiostrongylus cantonensis (Rat lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Metastrongyloidea; Angiostrongylidae; Angiostrongylus.
OX   NCBI_TaxID=6313 {ECO:0000313|Proteomes:UP000035642, ECO:0000313|WBParaSite:ACAC_0001055301-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000035642, ECO:0000313|WBParaSite:ACAC_0001055301-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A.;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:ACAC_0001055301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; ACAC_0001055301-mRNA-1; ACAC_0001055301-mRNA-1; ACAC_0001055301.
DR   Proteomes; UP000035642; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035642};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035642};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    410    434       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    473       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    569       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    581    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    666    685       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   819 AA;  94094 MW;  4192F2DB71F4605F CRC64;
     MSEPEPDQPG IYRSEQVTLA QLFLQSEAAY QCVAELGELG LVQFRDLNPD TSSFQRKYVN
     EVRRCDEMER KLRYLEREIK KDQIPMLDTG ENPDAPQPRE MIDLEATFEK LENELREVNR
     NEETLRKNFS ELTELKHILR KTQTFFEEVE HDRRRFGETT RRRTLSGEQE PLIITAEEEL
     SYGMSLSLTM LRLGFVAGVI RRERLPAFER LLWRACRGNV FLRTSEIDDA LNDTVTGEPV
     NKTVFIIFFQ GDQLKTKVKK ICEGFRATLY PCPDTPQERR EMSIGVMTRI EDLKTVLGQT
     QDHRHRVLVA ASKNVRMWLT KVRKIKSIYH TLNLFNIDVT HRIMTSLKKK EESGSQVPSI
     LNRMETSEAP PTYHKTNKFT KGFQNIVDAY GVATYREINP APYTMISFPF LFAVMFGDLG
     HGAIMILAAL FFILKEKQLE AARIKDEIFQ TFFGGRYVIF LMGAFSIYTG LLYNDVFSKS
     LNIFGSGWTN CYDFHEIDRH GFSPEKQLML IPEKAYDSAG GPYPIGVDPV WNLAESNKLT
     FLNSMKMKIS VILGIAQMTF GVLLSYQNYK YFKSELDIKF MFIPQIVFLT SIFMYLCLEI
     IVKWIRFTAG DSIFGYKYPG SNCAPSLLIG LINMFMMKPL DSGFVEADGE QKFQCHLNHW
     YPGQGFFQTL FVLIAIACVP VMLFAKPYML WKADKERRES GHRQLSVRAD MNGDDAEVVH
     TEPKTLATSS GNNSGHGAEP FELGEVMVYQ AIHTIEFVLG SISHTASYLR LWALSLAHAR
     FLLTRSVFAF ATTYFIFENI RVFRLCSAQI RVGIEGAQK
//
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