ID   A0A0K0DS34_STRER        Unreviewed;      1161 AA.
AC   A0A0K0DS34;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Integrase catalytic domain-containing protein {ECO:0000313|WBParaSite:SSTP_0000004700.1};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000004700.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000004700.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   AlphaFoldDB; A0A0K0DS34; -.
DR   STRING; 6248.A0A0K0DS34; -.
DR   WBParaSite; SSTP_0000004700.1; SSTP_0000004700.1; SSTP_0000004700.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00303; retropepsin_like; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   Pfam; PF08284; RVP_2; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1029..1161
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          259..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..288
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1161 AA;  134365 MW;  374CD7E3FF26837E CRC64;
     MLSSEEDHIN YRIIQAALKT LDPSLPEDTI HEISLTNLSL ARLSHTKLYS KLNKILSNLR
     YSDSEDSETT VDLDSTFIVE MDNINALPIS NTWMTVAPFD PKQSFQQWYK TFDLHLQFDK
     LDEERKLIAL KLRGGDAIQR HIEELPQSQQ TYTSIIKSLT DTFTGAISVE TASTRLISYK
     FNYSEFRKSL YSYVELIDKA NPSTRQENFR SLVEERLMNN LRGGLAKYLR NQRRHYTTLE
     EMLEDLILEN NLQRDHHQKK REKCKIHQTS NHTNDECRRQ KIKSENQPRD ESSFVSSNLI
     QMSAYIYNKP CNVLIDSGAT CTLVSPSFAK SLKVDHDTSP SYIKTAGSPS FAKQINTPLH
     LNISNCSYQT NTNNYIAGHN FNNYQVILGM NYLVPLKCSI STHKRKAYFS QPPISNFVLS
     PPNDSLKEEE EKFKKMIKEK YSSVEPRGDL DVGPGLFSTP PQEFYTIPPI GIKHYSSSPS
     EDDDQIIKQM LDQDIIEKST LLTTLPYYFL IKRGENGKPQ KQNGKIRKRF ILDCREINHR
     TLMVPFHCLS LQVLLQQLKE FNYGSTIDLH QDTKFTSSRG LQWALKIHHH FFKIIWNYFY
     QISDININLI QIYFLYMDDI LILTNGSISL HLQVVEDIIK IIHSKNGKIS LNKCCLLRTS
     LNFLSWTFSK NTITPTISHL IQNTSLPQTK KELYSKLQCF NYFRLSIPNI HERTHDLYQL
     IKGQKNEKIQ WTTELSNKYY SFCQYLFNKP TIYMYDDKQP LILKVDGSNI GVGGFLCQKD
     VQGIVRPLGY FSYPLQKTKN PRSPTYIELL AIAKGISTFR YLIQGKELII ESDHRPLAGL
     IKNSTAPKFL EQISTITQYT TNIKYINGHN NQFADLLSRI FNDIKSEMNN TTEMPKKRGR
     PRKLLDPMSH NDKRYINYET LPINIAALQK MDGELISSLE KGEFDNQQIE EYNGVIVTKN
     SKLPIITNEE TIQSIFKICH DQTGHWNYLA TKEIIQKNVY IPDLEKRIKN YILNCDTCNR
     FNSKNFEKAN SQEQIYKVFE CLAADAMGPM EMTKNNSIHI LLYVCPASKF VIAHAMPDLT
     AKSIIYSLQQ IKASYTLPKV LRTDGAKYWT AKEVEQYLET NHVEHSISTP NNSTENAFAE
     RYLRTLQIVI GKLLLDYPSY Q
//