ID   A0A0K0DSP2_STRER        Unreviewed;       494 AA.
AC   A0A0K0DSP2;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000025400.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000025400.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC       {ECO:0000256|ARBA:ARBA00005884}.
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DR   AlphaFoldDB; A0A0K0DSP2; -.
DR   STRING; 6248.A0A0K0DSP2; -.
DR   WBParaSite; SSTP_0000025400.1; SSTP_0000025400.1; SSTP_0000025400.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20343; BRcat_RBR_HHARI-like; 1.
DR   CDD; cd20356; Rcat_RBR_HHARI-like; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR045840; Ariadne.
DR   InterPro; IPR048962; ARIH1-like_UBL.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685:SF212; E3 UBIQUITIN-PROTEIN LIGASE ARIH1; 1.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF21235; ARI1_UBAl; 1.
DR   Pfam; PF19422; Ariadne; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          123..329
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
SQ   SEQUENCE   494 AA;  58158 MW;  7C712537D8D6AC48 CRC64;
     MSFFSLIPTM SDEYLSSDNE YGDMSDSSES STSYIEHDQQ STSNHYKLLE NKHLVSEMDK
     ILDEVRSVTN LPKTYCRILL HQYKWDKQTL IEKYYEQESD AFFKKYNLIN PSSLNRSIIS
     VATRGTCNIC CSEEVLTESI CGHKYCNQCW LHYFKTKITD HCDHIISCQE YGCDIAVDDD
     MVIKIIGQSA PLICRYKKLI TKSFVESNKN LKYCPNPECY YITKIISIED EPITCQCGFV
     YCFKCGHEWH EPLHCDIFKR WLRKCSDDSE TSNWLNVHTK ECPKCASTIE KNGGCNHMIC
     HRCKYEYCWV CLQEWGPHGN NWYSCNKYNE KRDSNNHTNV TQARAKLNRY LHYYQRYANH
     QQSLRLEGNL NHSVEEAMQL FQNEGMSWIE VQFLKTAVSI LSNCRKTLMY SYAFAYYLER
     GNQTDIFEGN QADLESSTES LSASLERLSE DTNMMREIKR KIQDKCRYVD RRRVVLLNHI
     KEGYEQKSWI FTSD
//