ID   A0A0K0DTU5_STRER        Unreviewed;       986 AA.
AC   A0A0K0DTU5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=CCHC-type domain-containing protein {ECO:0000313|WBParaSite:SSTP_0000066100.1};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000066100.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0000066100.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0K0DTU5; -.
DR   STRING; 6248.A0A0K0DTU5; -.
DR   WBParaSite; SSTP_0000066100.1; SSTP_0000066100.1; SSTP_0000066100.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          182..195
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          866..986
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          393..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  113730 MW;  5E76CFCEFAA3B946 CRC64;
     MTYNQEIRQI FRVILSKPVN NLYARAYRTA CRLYPAASYP AILAFTRSTA LQSYRAGTDI
     ELLRAVKQKN NESVHNYTND FMQLDNYEEK PFTEADAFIR RELYKIYMHG LLSMIVNRIP
     IPPTNRQCLK NISEQNAVVE DDLKTKAKAG KSRQQHYQTR FQTAAIEKSV QKSKYDKTVT
     ICHNCDKKGH WASECGETPV QSLIICPIIE ADDVKWSKPI YIGDCLIETI YPSCTEYYIP
     MIWKSGQLYS VKGEPALVIK ANKENFKECP CKQIGRGFVI GDKTCYSFLT IAVDDRSYAL
     HFAHPDIDKV IATPKATELG WALTEYYIQN KNRRSDKSNT TPVLKDLTFA MTNTASNQKE
     TEDIHQLLEE IIVKTKELKD KQDKNIAKMQ LEDTLPETTT TKSTTTKKPT TTTTEAAKTK
     TPKATTVIKP TVPTTTETII STTTAKLLAI DSILFDTPRG DHSDNDEFRT PIQTGRRTVY
     KKVLEEVLRR LRKAGLKAKL AKTVFLQNEV KFLGFVIDHN GIKVDPDKVE AIAKMKIPWD
     RKSLRSLLGA TQYLRRFIKD YAKVAAPLTM LLSEKIEFRW GPEQDKAFKI LKEKLTNAPI
     LAKPDLGRSF IIHTDASDYA ISAVLLQEDQ EKRLRVIAYA SQTLRDVEKR WQITEKEALA
     VVFAVRKFHY YDTGKTTDIY TDQRAVVAIK RAKENQTKLR RYQLALIAYN LNIYYKEGKA
     NVLADLLSRN TTLAIKVSQP PKDILEIVDN FKNPHNIETW KLSEEEKTLL QKHFGNKVQN
     HDNIAIVIIN GTPNCYVPEK NREEFIKHYH GHPIFEEHFG QKRIEEAIKK YFWWHSMKIQ
     FNCEICHKIK YHPGTTYSQW LGKWDIPKIP FERINMDIRG PLPETLRFNK YLLVIVDDLS
     MYALTLPLWK TNSECIIEAL ITKVFPIFGL PKMIRYDNAQ YFNSASIVKA LNEWGIGMRN
     STPYNHNSNG EVERFNRVIN EIFSCY
//