ID A0A0K0E045_STRER Unreviewed; 2536 AA.
AC A0A0K0E045;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Hemicentin-1 {ECO:0000313|WBParaSite:SSTP_0000286100.1};
OS Strongyloides stercoralis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0000286100.1};
RN [1] {ECO:0000313|WBParaSite:SSTP_0000286100.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A0K0E045; -.
DR STRING; 6248.A0A0K0E045; -.
DR WBParaSite; SSTP_0000286100.1; SSTP_0000286100.1; SSTP_0000286100.
DR Proteomes; UP000035681; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 20.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF8; WRAPPER_REGA-1_KLINGON HOMOLOG; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF07679; I-set; 12.
DR Pfam; PF13927; Ig_3; 7.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00409; IG; 19.
DR SMART; SM00408; IGc2; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 20.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50835; IG_LIKE; 19.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 60..147
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 152..241
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 244..329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 334..407
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 417..503
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 508..597
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 602..698
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 707..796
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 801..894
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 899..987
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 994..1082
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1087..1176
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1181..1262
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1269..1359
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1364..1451
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1456..1543
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1548..1634
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1697..1781
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1885..1958
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2266..2304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2341..2376
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 2345..2355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2536 AA; 283267 MW; 9DA95F6CF20F79EF CRC64;
MYNEMNGEEI VGNEELFRND RQFLDIEEVS ENDAGHYTCI AINDGGSAEK DIIYSILNPP
KMMESKNSIE GKEGNTTTFI CPLHEDNAEI EWFKNDIPVK NIPGSNFQIT KNGKHLTIIK
IQKNDGGKFR CLAKNSAGED NAIFDFNVLI PPSISGPSFR TIDNPINQPT TLNCNISGIP
FPEIEWLFDG KPLLVNSGYD IKNNGKTLFI PSTDTTHKGR YTCKGYNKIG NIEADFLLQV
TEPPNIKPML KEQKVIEGQG ITIRCEVEGS KPSKVEWRKN GEPYTSDLTH SSSFMHYIYI
KESKLSTSGN YTCIASNNAG SVNDTTKLIV LVPPSIIEGE KIIQLKEYQD MTLDCTATGI
PSPIIKWKKG DTPLEVVGEK LNLYNVSRND NGRYTCEATS ESGIAVADFI VDVLERPRIR
QSPSDIRVKE SSIAKFECKS EGNPTPSVTW LRGGRPIQDT SGLLFSPRGE TMMIPHTKKS
DSGRYSCVAK NSGGETEKEF TLTILTAPSI EESIDQNPRV IHGNDLVISC PAIGNPKPNI
IWFKNDQEII FEEEEPKYTL INNTNLLIKN ADVNDGVKFT CKAENEVASI DTDYSVEIIA
KPKFGSKGQT SYNVVVNNDV TIECPVDIPQ SEFSFFGFKR KNSFKINWTK NGEVINNVKG
KYYISKDSLK LTIHNAQLSS AGKYSCEVSN EAGEAEIDIN LKVLIPPKID KSNLIQNPLA
ILNKTISLEC PASGIPQPTV TWLRDGVIIL FEDDKYTEDG NGQILNIKKV DINDQGKYTC
LVESTAGKTS EDFDLHVLIP PQMEVYETQH INKREGEVLT LVCPIKVPIE QNVPIDIVWY
KNTIPLDPLS SNHFKLLSDG RRYQVLSASF VDSANYTCQA VNRAGEAKAN FEVNILSKPI
IDTTKIDLEP HFFENSDVEL WCPTTGNPPP TIIWYKNGIE VDPSKDDRIK FSPDKSTITI
TNVNSNESGS WVCLAENDAG TSELEITLDV WIKPSVEVYS DTGVIRKVGS PVSIHCNVTG
NPEPEIIWRF NGNIITSSVD GVRLSLKNTR LDIPRLSQSN VGEYSCHATN SVGSAEKDIW
VDVLVPPTID RDIADPNPRI PTEKNLTLTC LVDGKPDPEI SWYLNGSLIS QFDKRYSISE
EGRYLQIFNI SLLDSGIYKC DAVNEAGHDE FEYFVDVDQA PYIYNSGTVR IEEGKVSILE
CKAIGEPTPK ITWQRNGVHV ESGDRYIVND GVLKIVDTRL TDIGIYICFA ENEAGQDQQA
FTLEILIKPT IRESSPSETV VPTGGNFELY CISNGYPQPE MKWFLNDESM ELLGDDSNID
FSIDHEILTV KHLHSSGNYI FKCQASNSAG KDSKEMAVKV LLPPTLVSDD KKVLNITEGE
PALLTCDIHE TYRDSIVWTK NDETINFDAG IFLSDDNSFI QINKTKLSDA GNYKCSASNA
AGNTHQEILL NIGIPPKITE KERLITFKEG ERGEIWCEAT GVPNPKITWL KDNEPLQHTA
IDKMSGEIKS SAIFESITKA SEGTYTCKAE NWAGTIYKDF DLAVLIPPTI YPERLNITAR
PNSIVLLECN ATGNPIPVIS WVKLPGVNIT GSEKKYKVVG STLAINNITS EDDGFYHCSA
KSDAGFAIGV RKLSVLSDNN KIKLVHVECD ENGEPISKRF VSNRGDAPEN SDLIEMQLEH
IQLPENNTDG VIIRCLPVLF TETPEHTNVS VGEMLKLKCG AEGMPTPEIK WMKNGKYINN
TLKAYGNSIL KMEIKHTNQS GTYTCVASNS ISTKRVNAII TVNDVYEKNK NSSKLSKDVT
TIECSLPIWK RSIRNKKVDK NVVWKMDNEL VDQNTNGVHL LNNNSLVVGY KAEKEELDKY
IDCYVDGNHG NLKLSHVKIP KDKPPKVVIR PTRIHAKPTF NITIDCRLKR GNPLTTRIRW
SKNNVPVFTD NFKFKVLSNN SLAIFNIESN DGGNYKCRGY NSLGKSWDGV KLIVEHGPTN
IKSAIKNQAL TLNHDIEYND NGIEVTTFVE DLIGNKSKLS KNIANIITSP YPLLSNGKDI
PNLRKTKGKF NRTTQYFFGN GEKITVNQKG KGLDNKDILD METDIEDVEM FELEPGVYIG
NGQSMVTLNN KHKIGFEWKD EIKYDPNYED RINVNDPKTT YITATPTIGS TKSKLNTKFE
TKIDCPKGFY LINGKCEDID ECLSTEPCDD PEAECINYDG SYECRITCPK GFSSKLDGTC
VDIDECAIGP DICLGNKECI NLEGSYKCID KCEDGYELDI YDNCVDIDEC SLNICGQSMS
CTNTLGSYIC TCPEGYPPIN NECSGLVFDE ARPVYNIEFN DSQSTIKCPP NYWWNGTICK
DIDECSFDAP CQHQCINLAG TYTCSCPEGY RLDEKTLKCI DINECLEVSN LCPYNSLCIN
ILGSYYCQNA PCRKGYTFID NICKPKCRGP CNVRPIRIET ISTRRGLPKN TPLLRLTTQD
KDGHLMKNTD YHMSYHYKYR IENIDGRGIV YNNEALNEED IHRLVITSTP KDINNNTIVN
KIQQTVLYIA ISAYDF
//
