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Database: UniProt
Entry: A0A0K0ESU5_STRER
LinkDB: A0A0K0ESU5_STRER
Original site: A0A0K0ESU5_STRER 
ID   A0A0K0ESU5_STRER        Unreviewed;       905 AA.
AC   A0A0K0ESU5;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   20-JAN-2016, entry version 4.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Panagrolaimoidea; Strongyloididae; Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|Proteomes:UP000035681, ECO:0000313|WBParaSite:SSTP_0001252400.1};
RN   [1] {ECO:0000313|Proteomes:UP000035681, ECO:0000313|WBParaSite:SSTP_0001252400.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SSTP_0001252400.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; SSTP_0001252400.1; SSTP_0001252400.1; SSTP_0001252400.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035681};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    415    447       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    467    486       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    564    585       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    597    620       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    632    653       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    689    708       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    833    857       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      112    139       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   905 AA;  104647 MW;  D45F9EF0AA383BCE CRC64;
     MSSTFRSEPM KLYQLIIQKD GAFNVLAELG QHELIHFNEY KASSNVLQKT YIREVQRCIS
     IERSLKNLAN QIWQSNIPEG KNVLKFNHFS DIITEVGKPK DLLTIEYEIE EREKVVMELS
     KYEENLKNQL DEMKEFEQVL DKVNDFFIDH VDDEAINTLE NVASSERISL INERDIENEK
     EASNAFNEVT TPWFVAGIIG AQKRFAFERV LWRACRRTAF VRTTLVEIEE NVFSPKKPER
     CVFIIFFKGK KLQDIVDRVC DGFGAKQYPC PKTAKDRHRS ELEVKIRMDD LVTVINSTIS
     QKGEVLTSTA KQINEWWKEV HLQKTIYHHL NSFKFDTSGN FFIAEAWVPD TYINQVKDIL
     QECVNKRGAV LPILNVIDSS EIPPTLTITN KFTNCFQGIV NSYGVPTYRE INPSLFTIIT
     FPFLFAIMFG DAGHGIILAI FGFYLIYKEK IIEKIDELDE ISSIFFGGRY IIFLMGLMSI
     YTGFIYNDAF AKSFNIFGSS WKIPYNENNM NNWINESTKK SFDLTLDPLY AYNDTLGPYP
     IGVDPIWNLA RNKLTFLNSM KMKASILIGV SQMTFGIFLS FFNYWEKKSL IDIFTNFIPQ
     LFFLTSIFIY LCIQIIVKWI YYSVKPANVF NFYYPGSHCA PSLLIGLINL VMLKKRDVGF
     VNKNETEYKE LKTCYLNQWY PNQSDFEQIL LLTAFICIPI MLLGKPLYES IKRKRKTKTY
     LDSKNINESL ELITLNSPTE ENNVKHIHIH KYSSSNTINT SVCEKKTSLS VEHGESFGNI
     IVHQAIHSIE FILGCISHTA SYLRLWALSL AHAQLSEILW EKVLVEGMNI LPIYGPIATF
     IAFFIFFILT ISILVLMEGL SAFLHALRLH WVEFQSKFYE GNGYSFNPFS LKAALKILKP
     QYAKE
//
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