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Database: UniProt
Entry: A0A0K0FLK1_9BILA
LinkDB: A0A0K0FLK1_9BILA
Original site: A0A0K0FLK1_9BILA 
ID   A0A0K0FLK1_9BILA        Unreviewed;       846 AA.
AC   A0A0K0FLK1;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   07-JUN-2017, entry version 6.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Strongyloides venezuelensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Panagrolaimoidea; Strongyloididae; Strongyloides.
OX   NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0991600.1};
RN   [1] {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0991600.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A, De Silva N.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SVE_0991600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; SVE_0991600.1; SVE_0991600.1; SVE_0991600.
DR   Proteomes; UP000035680; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000035680};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    416    441       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    462    479       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    554    576       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    583    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    679    698       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    785    811       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   846 AA;  96246 MW;  E15C225C1C2967C9 CRC64;
     MGSLYRSELM TFCELYLPSE AAYNCIAELG EFGLCQFKDL NEEVTSYSRK FHKELSMCDE
     MERIVENIKS CLNEDHIKFR DVNGNIPVPE QKEFSGMHTK LTLIQNELTQ VNGSMDSLKK
     NYLELNECKH VLSKVTGLLD SNIKAVATKS ISEAEHGHAG PVYTSDEVVA EDFTTFKDRD
     ESELSFICGA INSTKIITFE KLIWRMTRGK AYVRSQPIDD DTNTLFPNDT NKSAFIVFFI
     GKQLKYKIRR VCDAFHCHII DSPENPNLRR IALGKLETQI SDLIVVINKT SEYKNRILFG
     TSQHISQWEI EVMKVKSVYN ILNYLNVDVT HKCLIGELWT PTKEIENVKS YLRIGQKKAE
     CSVQPILSPI HTHDIPPTYN NLNKFTRGFQ NIVDAYGIAN YREINPAPWT IISFPFIFAI
     MFGDSGHGII MLLSALALVL FEKKIDAAKI KDEIFNTFYG GRYVILLMGC FSIYTGLIYN
     DFYSKSINIF GSSWKNPYNH TIIMSRLLDD TESLTLPIKE AYDRDNGPYP FGVDPIWNLA
     SNKLTFLNAM KMKMSILIGI SQMAFGVFLS LVNYFHRKSI LDVLFMFIPQ LLFLSCIFVY
     LCIQVILKWL FFSVTPGFVF GQYYPSSNCA PSLLIGLINM FMLKHGEEGF VSGNVPTGKV
     YDQCYLQQWY PGQGTTETIL LLIAVISIPV MLLFKPLIQL YMHKRGMPVS GGHGHDEEFN
     FGDVMVYQAI HTIEYALGCI SHTASYLRLW ALSLAHAQLS EVLWTMVLHI ALSMSGYAGS
     VAVYFIFWAF SILSIAILVL MEGLSAFLHA LRLHWVEFQS KFYLGTGILF EPFSFVAIQK
     AKEGLD
//
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