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Database: UniProt
Entry: A0A0K0FNZ1_9BILA
LinkDB: A0A0K0FNZ1_9BILA
Original site: A0A0K0FNZ1_9BILA 
ID   A0A0K0FNZ1_9BILA        Unreviewed;      5313 AA.
AC   A0A0K0FNZ1;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   SubName: Full=Ryanodine receptor 1 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:SVE_1084200.3};
OS   Strongyloides venezuelensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Panagrolaimoidea; Strongyloididae; Strongyloides.
OX   NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_1084200.3};
RN   [1] {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_1084200.3}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A, De Silva N.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SVE_1084200.3}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   WBParaSite; SVE_1084200.3; SVE_1084200.3; SVE_1084200.
DR   Proteomes; UP000035680; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035680};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4857   4874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4927   4949       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5065   5087       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5107   5132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5192   5211       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      153    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    260       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      269    324       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      330    387       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      395    453       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      633    855       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1073   1267       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1560   1776       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4402   4437       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4440   4472       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4415   4426       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4450   4461       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5313 AA;  605443 MW;  6AE19EFE5DB8E026 CRC64;
     MVEKEETPGG EQDDVSFLRT KVFFISYYKK VRICYFLLIR RDMVFKYKNL YDFVDEIEIF
     SHENEYLSKG DIVALTCVSS NTKDGAMGSE RVCLSTEGFA NRMCVLENVS DKDVPPDISQ
     CMLYIDNALS VRALQEMMSA GNEVKGTSGS GGHKTLLYGH AVQLKHVQSE MYLACLSSCS
     SSDKLSFDVG VQESNDGETS WWTIHPASKQ RSEGEKVRVG DDVILVSVAT ERYLHMALGK
     NDQYIVIASF HQTLWNIASV SSGSIRNRNM GVLFGNDVLR LFHGNDECLT IPENWSENHA
     HNVIIYEGGN AVSQARSLWR VELIRMKWHG AMIGYDQTFR IRHITTGRYL GVLDNAVILL
     QKDKADFETT AFVMCPNKDP KKAMLEEKEE EGMGVATIRY GETDTFIQHH KTQLWLSYQT
     TEVTKKGLGK VEEKKAVALK DGHMDDCYTF FMALEEESKS ARVIRKCSSV LNRFLKGVEA
     LQNEGNQSLE WKRVNLNSVL KLMEDLIEYF AQPTDEHTFE ERQVRFRALR SRQDLFQEEG
     VLNMILDTID KFSQMEALPD FNGLIGDKNH AIWEEISTYL YLLVAAMIKG NHSNCAQFAA
     AQRLDWLFGR LSNPQSAEGI LDVLYCVLTE SPEALNMINE GHIKSVISLL EKVGRDPKVL
     DVLSSLCEGN GMAVRSSQNT IADHLLPGKD LLLQTVMRDH VSSVMPNILV GVVEGSCLYR
     KWYFETEVEH IESTTKSQPL LRIGWANTLG FKPYPGSGNG WGCNGCGDDF FSYGFDGRYM
     WFSGKARNSG NSRLFAKGDV IGCSLNLTIP EIRFYLNGIP IQTTFRNFNF DGFFFPVMSL
     SSKVSCRFLF GGDHGKLKYG PPDGFSPVYE AVENKLEIAE VLSFGDLTKN IYSGTSNILN
     NIEPFVPEPV DISKITLSSF AVQHHTQFAQ NLHELWAMKK ISLGWTYSPN RSETLKTHPC
     LISFEQLPST EKEYNLKLAI DTMRTIEALG YHMILDKPPT RMRPIRLPNN FLMSNGFKPQ
     PLDTHEIILS EALETTLVEA LAKNIHNVWA REKIKRGYTF GVNEIMTNTQ KRSPHLVPYE
     NVDKRIKEAN KETARETIKV LQLFGIFLEA PAIEHDEQAE KEFTAKKASS ITYRAETSYA
     VTSGKWYFEF EVLTNGFMRI GWSDISCCPD TKVGSDDKSY AFDGYLGKKW HQGAETYGKE
     WKVGDIVGCF LDLNDRTISF SLNGELLLDP SGSEMAFDNI INGDGFVPCM TLSAGQRARL
     NFGQDINSLK FFTTCGLQEG YEPFCVNMYR QMPMWYGKSL PMFREISHVE SALEMSRILP
     TSNTPPCLKL TLKATNNDGS SSDKINHMEF LRLSLPVKVN SSLIYNDEKE RTIEAMKEYQ
     YSHMIEHEED SERDAKKKKK GLLSAFGRKG KRESDDDLHG GKATLHSSIG EFDVSEGAAA
     HRQRERLKIL IEFGCHSYDS TVLTYLTDGK KDTEKKRFWK DYLSSRDEGG DSHSDSQHDK
     VSTKSKEKKP GIFKRIRDAS HTRQKEKPPP EPKKYRTTEI LPATIMAKRD SSVFMDSHQG
     SIDVLADMPV SGPGRKSFKR KGSKNAANMK QYQATRGSII STALGLEDSH FITDKDSDVQ
     AMQTLGEGIN DYYYGLRIFP GQDPSSVYVG WVTPQYHSYV SSFKNSQAVR SCKFASIEFG
     GDGLTMPQEL IEFRNCYLLN AGELLTCVND TTNTKVTGVL IGCVIDTSAG ELSFYVEGQD
     TGRKFKLEAG LMLYPAAFVI PTSSEVCQFE LGRVKYTWPL SAALFKSSAK SLIPYCPPRL
     SVQVLTPYHW ARVPNECLRT TALKLSDTRG WSVLCNDPVR VMLIHIPEKN KSYDILELIE
     MPELLTFHRQ TLNLYCKLAS HGNQKVSHIL CQHVDEDQIM YAIKNHYLSG SMRQGFHDFL
     IACHLKSHTD AIQSTSHEYV LPLVSELMIK DIFSDDSDCR YPHILGKSLC IRPVVKSDPP
     VKSFTKDSQV KLLPPAFNFK ALKNYVMSAF GEAMHHAVMN CRDLIGGNNL DHFEPLFKLF
     DHLLIMGLFS DDELIEILKI LHPAAFDENY KPGTKLKGIL DIDVAEGVKL QIVNILDHLC
     DIQLRNRIES LISFSEGFVG ELQQDQCARY MDIKQTDMPP AEAARKTKEF RCPPNEQMYR
     LLGCKKKEDK EGILLDDDVE YDQCPMADTL QDQLRDFCSL LVTKCGCNDV EEDVGKIEEI
     IDLDEETSWV DSLAHLVVSV PPNAIDDEEV VAKQGTKNFR NMIVQLLKQW ATDNIIESNE
     LIRRMFALLL RQYNGIRELM DSMNQTYVFH ERNVEDVQNF ITFLMQIREL LTVQFETTEE
     VILKRALWQL MNNRIFFQHP DLMRLLKVHE NVMSIMMNVL TAQQNTVEIE RDPDDPVTSS
     PIKDASEMVV ACSRFLCYFC RTSRQNQKAM FEHLSFLLDN ATMLLARPSL RGSVPLDVAY
     SSFMDNNELA LALKEEELDK VTVYLSRCGL QPNSELITKG YPDIGWDPLE GERYIDFLRF
     CVWINGENVE ENANLVIRLL IRRPECLGVA LKGEGQGLFN AFQEAIILSE DIDELENGIA
     IDFLRSPIFK DHPHYPLKET EGDDYVDLGA SILDFYSSLV DLLAKCAPDP MTIQEGKGDS
     VRARAILRSL ISLDDLGKIL ALRFKIPNLR SVLDGMFIPT VVLSQGNSPT NLATIADNLT
     RQKLLSLCND NNKPLHDDCL RNAKSLNVIY ENDEDSGESS YDTATESISS SPVRRAKSQA
     KRLRRKKILR LREFDIEENL DYIKMAKNRR RRSGIGLLFN NAGTQPGLMP SHKASVLLFL
     DRVYGIDSQE MLFSFMEQSF LPDLRAATMM DSPKATESDT ALALNRYLCN CVLPLLTNHS
     HFFSDAEHHS ALLDATLHTV YRMNRLQSLT KNQRDAVSDF LVAITRELPP PMMIKLLRKV
     IIDIQEMKDN VLVPLRIMTL HYERCNKYYG SGNQYGVANE TEKRLSMLLF YAIFDSLGSK
     PYDPELFGKA LPCLTAIGSA ISPDYSLTSG SEDTELAKVK DNEGSWSPKP IPIESITLKN
     ELNDMINKFA EHFHDSWSAR KLEKGWKFAE LYSRVEKTHP RLKPFKLLKD NEKSFYKDRC
     AESIKSLLAW GYIIEVYDFD AAEKSAQNHV SSGTCIADFN PKPVDLSNMN LEKDMMSAAE
     KIAENSHNIW CKKIFSDISG KPSSLPPSLV PWDLLTDFER RKNRFHAAEI LKFLQYHGYR
     VNMSRTNTPA KERTKTEGER GNVEKRFAYN LLEKLIQYLE QASYKMKSVK PSQELTRRNS
     FKKEGQDVKF FEKVVLPMMH AYFNAHKNYF LESSIMVQTG TASNKEKEMV ASLFCRLAAL
     LRIKNHAFGS VAKITVKCLQ GLTQALDLRT LVKINSDIIR TGLYTFFNNC AEDLLAAVNE
     LKNNGQYSLL RGQNLKSWIS LEFANQMIIP CLTTMFHHLA RNHFGADLLL DDIQAACYKI
     LDSLYMVTEI QTSYECRATI LHEVEKHRSS LGQCLSAFAS TFPVAFLEPE FNQNNKYSVL
     AKSADQSVQV QEMLQNLSSH IPTLEKLMER IEQTSQNLIP YNQAANVYDV DLPLACAYLT
     FWWNMGDDGP NSSQNALPIT RANSEYMNRI FCSLLAMIRD HIGSENAQWL CRVTYFAVPI
     IQHVTCDPVK EYLLPIAEKL CTAAELSYKE EERMRTHPDD ADEGTVGEDN AKLVRDVYAF
     FPILMKYTDL HRAKWLKNPS WESDRIYENV AVIFKIWSFS QIFKREELNY MAQFEEDQMN
     AGGEMKTGKA AIAERKKKRR EGFVKKDKHA NSIVIACLKR LLPVGLNVFG GRELDIVQQS
     KEKFLNKENE EKIREFIRGL SEIPVKTDPT DKNAWQLSLY TKIGKSQMRG KDLMNQDAVV
     EKIANMGQVV AILHTNTRLI EKRKRRYFRS DHPSAAHLCS WKKMLSSQRK RAVVACFRMV
     PLYGIPRHRG INFFLPAFSK LWLEEEDIGQ DKLVQDLCAD CEEVESSAVA RLFDDEGVLI
     GDENAEVVAN IAPDPLSQLI QCFQRAATTE ESQALVIASD DLYVNFAQVM AKSVHIEEED
     DDGGDDDGEV DQAQKEEMAQ TLRAEQAVLA DRGAAIMCLM YISASNGEPS EMVAKTLKLG
     IHLLSGGNTV IQKMLIDYLQ LKKDVRFFTS IAGLMNNCSV LNLEMFERQI KAEGLGMGAE
     LAAGENQNLN DAEFTCDLFR FLQLTCEGHN LDFQNYLRTQ PGHTTSVNLI NCIVDYLLRL
     QESVMDFYWH YSSKEMIDEG GKEYFLRAIQ VCSQVFNTLT ESIQGPCVGN QMTLANSRLW
     DAINGFFFLF AHMMEKLYKN STQLELLREF LNLQKDMIVL MLSMLEGNVL NGAIGKQMVD
     ALVESQQCVE MILKFSDMFL KLKDLTTSQA FQDFDTNKDG WISPKEFQKA MESQKMYSVE
     EITYLMMCTD VNNDGKVDYM EFTERFHNPA RDIGFNLAVL LTNLKEHITS DPRLEKIIEK
     ASTLLEYFDP YLGRIEIMGS SKRVEKIYFE IQESWLEQWS KQQIRDSKNA FLFNVLQDDG
     GDQGKLEAFI NFCEDTIFEM QHAAEISSGD ASDSKMERAL KQRDYFLRQT TAGTELTKTM
     QAGYSIGINA AAALKPENLQ KSFHHVSGKV HSMTWFQLIF GILQFCFFFI KEGFLVVFTI
     VATICRFLYY MTLSGKEDDI QKPNDLKQDR RTHIPKTNMF TKDLPDFKFE THHEYDAFGV
     HIPHEDHSNA KKMFPDGTPP PDPAPSIHIP TEETLNTPEN KSTPSPSPNY FSTPQSGSVH
     ETQSNLGSIT YLPPLSPQEQ GPIISNYEPK IAEIAAARSR GSILNMLARN FKTIEKMTLY
     LAFFINVILL FHRVDITHQN GETVSEKEVV ETGDDDENEE KDEFIYITGL SVPYISYEIT
     GWVLSQILYW LSVFHAFCSF ALLISFYQLK IPLITFKREK EVARKLMFDG CWITEDNTEE
     QGLMDTVTWY LDRIVIVSKS FPMKYWDKFV RRKTKAKYKD QVDEETLNKL LGEERAPGDT
     SFDYRYNCWL WFGVILTNAQ FLYRVGYLIC STCGVVVSPF FYAFHLIDVV LSFPMLKAIL
     QSVTHNLQQL ILTIMMTLVV VYLYTVLAFN FFRKFYVQEG EEGEEPDRKC HNMLTCFIYH
     FYAGVRAGGG IADEIESPYG DELEYPRMLY DISFFFFVII ILLAIMQGLI IDAFGELRDQ
     QEAATEKLES SCFICDIGKE AFDRMPRGFE IHTTKEHNFA NYLFFLQHLV NKDETEYTGQ
     ETYVREKYDN RDWEFFPVGE CFMKQYEDQL LQS
//
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