ID A0A0K0JE97_BRUMA Unreviewed; 1506 AA.
AC A0A0K0JE97;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=BMA-GTL-2 {ECO:0000313|EMBL:CDQ02415.1, ECO:0000313|WBParaSite:Bm4357.1};
GN Name=bma-gtl-2 {ECO:0000313|WormBase:Bm4357};
GN Synonyms=Bma-gtl-2 {ECO:0000313|EMBL:CDQ02415.1,
GN ECO:0000313|WBParaSite:Bm4357.1};
GN ORFNames=Bm4357 {ECO:0000313|WormBase:Bm4357}, BM_Bm4357
GN {ECO:0000313|EMBL:CDQ02415.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ02415.1};
RN [1] {ECO:0000313|EMBL:CDQ02415.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ02415.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ02415.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ02415.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm4357.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LN857024; CDQ02415.1; -; Genomic_DNA.
DR STRING; 6279.A0A0K0JE97; -.
DR EnsemblMetazoa; Bm4357.1; Bm4357.1; WBGene00224618.
DR WBParaSite; Bm4357.1; Bm4357.1; WBGene00224618.
DR WormBase; Bm4357; BM37696; WBGene00224618; Bma-gtl-2.
DR OMA; FEEDCID; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF45; GON-TWO LIKE (TRP SUBFAMILY); 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 937..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1048
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1068..1089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1144..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 181..449
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 943..1174
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1484..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1506 AA; 172711 MW; 00A188713FD7D192 CRC64;
MQDCASITNA EFISPPDDSN DDFNTSNFRR NSSVNSFRCT APRNSLSGQQ FYSLVNVPNN
YHTVENIKQK RSSKLFDRPE LFMHALTEKL KGPWIEQVFL KRECIRYIPT FGTNKCGCGL
SLNAHSLAVI SQFRATMMND EAAVRSSSQP VRWSITEHTK TAHTDAFGTL EFSGGAHAHK
AHYVRLGYDS DPSDIMYLME KIWGLDPPRL VITVHGGITN FEVQEKLGQV FRKGMLKAAQ
TTGAWIITAG IDAGVVRHVA TALDEAGISA RMRSKVVTIG IAPWGLLKRH EKLIGKDIVV
SYDPHSFSSK SKYATLNDRH SYFLLVDNGT NGRYGADIIL RKRFEEFIAR KQTIGLGTRH
VPVVCVVLEG GTCTIRAILQ YLANQPPVPV IVCDGSGRAS DLIAFARQHV QENGNLPREI
RVQLLTLVAS VFRYSTTPAE QILEEILCCA KHRDLLTVFR LSGNKKQDVD HAILSAILKG
QNLSAADQLA LTLVWNRVDI ARSDIFLANL NWNPHLLYNA MMEALVLDRV DFVKLLLENG
VSMKKFLTIS RLEQLYNMEQ DSILPLINDN MSIIDGRITL PKIGVVIERL MGNAYRCSYT
SRKFKNKYEK CRKKALISRI PSFRSLCATY SKTRKIAGEA RSNMRKRLRR ENKEDDDFQF
PFNDLMLWAV LSRRQEMARC MWMYGEEAMA KALAAIRLYK SMSKEAADEY IEVEVSNELR
EFAEEFKRES LSLLNHCHLQ DDAGTLRLLT AELPNWGHHT CLSLAVIANH RRFLAHPCCQ
ILLADLWHGG LGIKSYSNLK VILALAFPPS ILLLDVKARI SNRRMDSFTR HSFVIEGNEF
NNEKDDHSEN SASSSFHTSE HLKIRRKTRY KTSTFSQRMT NFFETANLIE ETLRVKSGAI
DPRKPVGTSL QEVEEMTRKT SWTTKFSIFY SAPITTFWIW LASYFVFLSV YTYVILIEFP
VKPTQVEWFL LAYVVAFVME HFRKLLVQEA STILEKIRVY FDRCWNYLTC LAIITFFIGF
AFRCNHLTRH SYGRIILSCN IVFWYIKLLD FMGVHPRLGP YIQMTGKMIV NMMYILALLL
VTLMSFGISR QAITYPHEKW QWLLIRNIFY KPYFMLYGEV YAGEIDTCGD EGINCVPGGW
IPPILMTIFL LVANILLINM LIAIFNNIFN ETNAIAQQVW LFQRYEQVME YENTPFFPPP
FTPISHLMIL FKYFWKLRKK SGRRGQGISK RGGFFDFSMK LSLNDDELRL LRDFEEDCMD
DLSRKKSLSQ PLQVDYELKT AAERTGSLQA QLNDMVNEDC SIKSFLREIE SKLYIIETNQ
QAMLKLLQSS ADKEANYNNL PSNTEAIRKK NLSVMRKKIL AEKRESVGKY ANISSSDDEE
CMRYTYKLPE ARNIYQITKR RSFILRDEVY TSITDTIEMP KVLYALDDPV QRAASPSIRA
TQLGNMAFKN LEKVSSCTMG REVRVQPSKW SITDLEDMCR EELSESANSD TNETAIRTPP
YIELNE
//
