ID A0A0K0JHC5_BRUMA Unreviewed; 789 AA.
AC A0A0K0JHC5; A0A0J9Y8A9;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN ORFNames=Bm5059 {ECO:0000313|EMBL:CDQ04376.1,
GN ECO:0000313|WormBase:Bm5059a}, BM_Bm5059
GN {ECO:0000313|EMBL:CDQ04376.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ04376.1};
RN [1] {ECO:0000313|EMBL:CDQ04376.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ04376.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ04376.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ04376.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm5059b.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
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DR EMBL; LN856244; CDQ04376.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K0JHC5; -.
DR EnsemblMetazoa; Bm5059b.1; Bm5059b.1; WBGene00225320.
DR WBParaSite; Bm5059b.1; Bm5059b.1; WBGene00225320.
DR WormBase; Bm5059a; BM44836; WBGene00225320; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF59; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT REGION 246..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 91620 MW; A7C56721D6D65466 CRC64;
MSEDRCRERL AEFPRRINVQ YLSVARGFTL TQEPFFHGLL IASVRFTLQK QLSKEHIQIP
ANLGRTMFGI LDETGLLQYG QVFVQFTNDV FLKTPPKAAA KTIVKGFVLI TKNPSIVAGD
VRIFEAVDLP ELRHLVDVVV FPQHGPRPHT DEMAGSDLDG DEYSVIWDDQ MLFSHNEEPM
DFSKLIRPPD ILKEDEVVRE MRRFYVEYVM QDSIGIIANA FLVNSDTFGI ASDVCMSIAE
KHSQSVDFPK TGQPPKPLVK EWSNGPDGKM IPPERPERWP DFMCKTHEPS YVSTRLVGQL
FRRIRLIDDV LTITRAHETQ SKVTVDPLLE YSGWESYEND ATLNLIAYSA HIRALMDNYG
IEDECQLYSG CFCKVRNRIS DRDGDDMSQF NTSFIIERKL TNIFMCFRCN FFAEFGDFMS
CTQQDDDLRN KDVIERRYCK YPTVEMKKKA SAYYIVCYRK VMKEKGERLL SFPWIVWDIL
ADIKKENAVL TSQNISTIDP LCELASNVIT CFCDDNKEDF DQTIGCLTDG ASGLHAIKRY
CRKYKGLDKL LYVLCKWGEQ QRLFEGRLKR EHLCLLLIQY GLGYISSDNM RDYVFLEQTD
EIPSENSNEC RDLNSLIGGI GKCFLQFLQY LSSRSFEKAK IFNFMKPNLG YHSILMRGQW
LDLHKAAIIT FYQIVLTNRF NEMSIFKREQ LHSCIEAEPF TIELPEDLCS FDENLREKMM
EYSNVRYLYL RRIPDRKNRV VVSAFGTLES LYRLRDILSV KPISTVQADS KKRSDMMLRL
VYERIQELP
//
