ID A0A0K0JRT8_BRUMA Unreviewed; 805 AA.
AC A0A0K0JRT8;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA repair and recombination protein RAD54-like {ECO:0000256|ARBA:ARBA00015341};
DE AltName: Full=Protein okra {ECO:0000256|ARBA:ARBA00029956};
GN ORFNames=Bm7309 {ECO:0000313|EMBL:CRZ22084.1,
GN ECO:0000313|WBParaSite:Bm7309a.1}, BM_Bm7309
GN {ECO:0000313|EMBL:CRZ22084.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CRZ22084.1};
RN [1] {ECO:0000313|EMBL:CRZ22084.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22084.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ22084.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22084.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7309a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- FUNCTION: Involved in mitotic DNA repair and meiotic recombination.
CC Functions in the recombinational DNA repair pathway. Essential for
CC interhomolog gene conversion (GC), but may have a less important role
CC in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51
CC enhances the ATPase activity of okr/Rad54.
CC {ECO:0000256|ARBA:ARBA00024776}.
CC -!- SUBUNIT: Interacts (via N-terminus) with spn-A/Rad51.
CC {ECO:0000256|ARBA:ARBA00011467}.
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DR EMBL; LN855481; CRZ22084.1; -; Genomic_DNA.
DR RefSeq; XP_001894090.1; XM_001894055.1.
DR STRING; 6279.A0A0K0JRT8; -.
DR EnsemblMetazoa; Bm7309a.1; Bm7309a.1; WBGene00227570.
DR GeneID; 6097544; -.
DR KEGG; bmy:BM_BM7309; -.
DR WBParaSite; Bm7309a.1; Bm7309a.1; WBGene00227570.
DR CTD; 6097544; -.
DR OMA; KCQTHEL; -.
DR OrthoDB; 5480555at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.850; SWI2/SNF2 ATPases, N-terminal domain; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022776};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 183..350
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 482..637
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 805 AA; 92123 MW; 5CD2E5E7120A81E4 CRC64;
MPDDDDDADT MVSQDEEIHC CYEVLYGKIS SRRHKRWQGD GLLYCRKRST ILLTEDGEEV
ARTSGYSFKQ LRELKVGSQL KVSNYEVEVQ NEPNPQKLAE FGKQPIVAEL AGSSAAHGES
SKKKRRITDQ IFISPLFGRD NPLDLVLDET KDDDGFVRRI AVDVQIARHL RPHQKDGVAF
MYRCLKNSHG GALLADEMGL GKTVQTISLI TALVKKRLNQ KPIIRKCIIV VPTSLLNNWY
AEFMRWSPQT QTMLFRILKS TDVKKLISYR NTSMIAIVSY EMIARTAAKL SVVSVDLLVC
DEAHRIKNLN GRLREQLQIL HAQRRLLLTG TPMQNDLEEF YSLVNFARPD LFISFLEFKN
LCEMESTRFN ELLSEVMLRR TAEVIHDLLP PKIDYIVWCR PSALQCSIYK NLKKFLPYDH
LTLIDALRKL CNHPFLLYQS MVVKRQTCKV EEREFYNAFL QSFPNTFNAF SLSTTDSGKL
NVFVELLATF REQEEKVVIV SNFTQTLDLL EELCRTLYYT ILRLDGSTEA KKRMEIVEEF
NSLSNKNYAF LLSAKAGGLG LNLVGANRMI LFDSDWNPAV DMQAMARIWR QGQEKPCHIF
RLITAGTVDE KILQRQIKKS SLNTIVEMVP VESLTHFSDE ELQDVFTLRD DAECETHFLL
ECQCDGRGFL PEELEVDQEI SSDENSAFYP DVEHVTTYSE GMDENYDHTS VAEDSLQPSL
NSLMQNCIDT IHFASTTNEV HEDDAGNKIL GDEAALSSSA LMGTLMRWQH HSPKHDQFES
LKAEADLEEC CLDEVSFIMK LVSNF
//
