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Database: UniProt
Entry: A0A0K0JRY7_BRUMA
LinkDB: A0A0K0JRY7_BRUMA
Original site: A0A0K0JRY7_BRUMA 
ID   A0A0K0JRY7_BRUMA        Unreviewed;       661 AA.
AC   A0A0K0JRY7;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   SubName: Full=BMA-TAX-4 {ECO:0000313|EMBL:CDP95269.1, ECO:0000313|WBParaSite:Bm7343};
GN   Name=bma-tax-4 {ECO:0000313|WormBase:Bm7343};
GN   Synonyms=Bma-tax-4 {ECO:0000313|EMBL:CDP95269.1};
GN   ORFNames=Bm7343 {ECO:0000313|WormBase:Bm7343}, BM_Bm7343
GN   {ECO:0000313|EMBL:CDP95269.1};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm7343};
RN   [1] {ECO:0000313|EMBL:CDP95269.1, ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm7343}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP95269.1,
RC   ECO:0000313|Proteomes:UP000006672};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|EMBL:CDP95269.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|EMBL:CDP95269.1};
RA   Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA   Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:Bm7343}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (SEP-2015) to UniProtKB.
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DR   EMBL; LN856937; CDP95269.1; -; Genomic_DNA.
DR   EnsemblMetazoa; Bm7343; Bm7343; WBGene00227604.
DR   WBParaSite; Bm7343; Bm7343; WBGene00227604.
DR   WormBase; Bm7343; BM33591; WBGene00227604; Bma-tax-4.
DR   OMA; TIGEMPP; -.
DR   OrthoDB; EOG091G03EW; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0034703; C:cation channel complex; IEA:EnsemblMetazoa.
DR   GO; GO:0097543; C:ciliary inversin compartment; IEA:EnsemblMetazoa.
DR   GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0097730; C:non-motile cilium; IEA:EnsemblMetazoa.
DR   GO; GO:0005222; F:intracellular cAMP activated cation channel activity; IEA:EnsemblMetazoa.
DR   GO; GO:0005223; F:intracellular cGMP activated cation channel activity; IEA:EnsemblMetazoa.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0009454; P:aerotaxis; IEA:EnsemblMetazoa.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0003031; P:detection of carbon dioxide; IEA:EnsemblMetazoa.
DR   GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IEA:EnsemblMetazoa.
DR   GO; GO:0007199; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; IEA:EnsemblMetazoa.
DR   GO; GO:0048609; P:multicellular organismal reproductive process; IEA:EnsemblMetazoa.
DR   GO; GO:0010754; P:negative regulation of cGMP-mediated signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0042048; P:olfactory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0007602; P:phototransduction; IEA:EnsemblMetazoa.
DR   GO; GO:0040010; P:positive regulation of growth rate; IEA:EnsemblMetazoa.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:EnsemblMetazoa.
DR   GO; GO:0030516; P:regulation of axon extension; IEA:EnsemblMetazoa.
DR   GO; GO:0055093; P:response to hyperoxia; IEA:EnsemblMetazoa.
DR   GO; GO:0040040; P:thermosensory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0043052; P:thermotaxis; IEA:EnsemblMetazoa.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR032406; CLZ_dom.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF16526; CLZ; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006672};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    127    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    268    292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    325    344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    351    373       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      455    569       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   661 AA;  76353 MW;  B6FF6336381E5A68 CRC64;
     MFSKSHDDTY ENHLKKRENL PNASAMKNIS NNDSFQKRHK SLRSNKICNI NEEENQAPST
     VTNTPQLNSI DSNKSCEKAK QSLIETSAPT SLTSKQPATE APSATTHETK WQYLLNKWVL
     DTKDEFYYYW LSIVSCAFTY NLIVVIGKLF FLLSRSVFND LAYGYYWIAW LLVDFIMDIT
     YVLDMFVRSR TGFLEQGLLV RDISRISKLY LKSLQFKLDI ISVLPFDLIL SFIFQRSIPY
     LRFNRIIRYP RFSDFVDRTE TRSSMPNAFR IFCVIVNIIV IIHWNACIYF FISEMIGLGS
     DGWVYGPLNK QSLPDGVEDT LVRRYIYSFY WSTLILTTIG EVPSPKRNIE FLFVIMDLMC
     GVLIFATIVG NVGSAISNMS LARTKFQNKM DGIKQYMKLR KVNKELETRV MKWFDYLWEH
     KQSLSDQRVL KVLPDKLQTE IAMQVHYETL RRVRIFQDCE AGLLAELVLK LQQQIFSPGD
     YICKKGDIGR EMYIVKRGKL QVVADDGIKV FATLQEGAVF GELSILNIAG SKNGNRRTAN
     VRSVGYTDLF ALNKNDLWTA LKEYPDARKL LIAKGREILR KDGLLDEDAP EEQMTAEEMA
     KNLQNTLKIM QTKMARFAAE FSSVKTKLLA RIEYLETQLA KYQINDNSTS SNDDYQMICD
     S
//
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