ID A0A0K0JT65_BRUMA Unreviewed; 820 AA.
AC A0A0K0JT65;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=BMA-HIM-14 {ECO:0000313|EMBL:CDQ04759.1, ECO:0000313|WBParaSite:Bm7630.1};
GN Name=bma-him-14 {ECO:0000313|WormBase:Bm7630};
GN Synonyms=Bma-him-14 {ECO:0000313|EMBL:CDQ04759.1,
GN ECO:0000313|WBParaSite:Bm7630.1};
GN ORFNames=Bm7630 {ECO:0000313|WormBase:Bm7630}, BM_Bm7630
GN {ECO:0000313|EMBL:CDQ04759.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm7630.1};
RN [1] {ECO:0000313|EMBL:CDQ04759.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ04759.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ04759.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ04759.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7630.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; LN856660; CDQ04759.1; -; Genomic_DNA.
DR RefSeq; XP_001897078.1; XM_001897043.1.
DR STRING; 6279.A0A0K0JT65; -.
DR EnsemblMetazoa; Bm7630.1; Bm7630.1; WBGene00227891.
DR GeneID; 6100526; -.
DR KEGG; bmy:BM_BM7630; -.
DR WBParaSite; Bm7630.1; Bm7630.1; WBGene00227891.
DR CTD; 6100526; -.
DR WormBase; Bm7630; BM00461; WBGene00227891; Bma-him-14.
DR OMA; KMTMLYK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 214..543
FT /note="DNA mismatch repair protein MutS core"
FT /evidence="ECO:0000259|SMART:SM00533"
FT DOMAIN 558..754
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 93058 MW; A5DDF0A32998765F CRC64;
MQRDTSSSAP KYRSFTSTRE RSRYSGNGTK LSLTSCIIFS VVEGRGSARG EIGLASIDAL
CSELHLWQFI DSASYARLRI QFQIQEPVEV IVPETFVEKA NSMNPVLELI RSTYPEVEIT
MINRRFFNDL KGIELLKQLS SSESSNITPE VYKKYYCMAA AAALIKYVEC IQNILFAQNS
LKVTYLFAEK SCFIDVNTMR NVEVVERIHL KQKTLGRSLF SVLNTCLTSG GVRLLRSSLL
QPSADLSMIE TRLDAIEELI SNQPKFDRLR AIIAGISDIY RLITVCCYLQ NQNETVRIVE
HRITQILNLQ QTLHLIKPLK DALKNSRAHL FRLCYNHLDD ERFESIMNIL DEKLNTTCKV
GERSSLALRQ KRCYAIRDGI DQMIDVMRKA YEELLRDTRE KGNEDASEIS EAKLIYTASR
GFHFCIPCLD PVARIKLPSQ FIDMVRNRTS VSCTTRSLLR YNERIDEVVN EITIRSNVIV
VELLNKIRLM IPCLYHAIEA ISMVDFISSL AVYAMKIPSV RPSFSPSMSM IIKRGRHPLL
DLASENFIPN DVYLSPESRI NIITGPNMAG KSTYLKQICL LHVLAQTGSF VPAEMAAFPI
LTRIFSRIGH NDDLTANLSA FAVEMSEMAP ILSTADSLSL VLIDELACST AYDEGLSICF
AICEELLRRK AYVVFATHYL DLASLATMYP SVENFHFSAN TVKIKQDDDS EVEKLHCSHQ
LYTGPYNGPL YAFNLADLTT FPREVLTEAH TLAMSLRTQR NVMVEMDDEM RQRRSIIRFA
CKLRSMLPLL TKTDTDAAAP YLSKLRDQLF QDLPPLTNDQ
//
