ID A0A0K0Y3T0_9RHOB Unreviewed; 788 AA.
AC A0A0K0Y3T0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:AKS45638.1};
GN ORFNames=OSB_10820 {ECO:0000313|EMBL:AKS45638.1}, SAMN05444287_0736
GN {ECO:0000313|EMBL:SIN97356.1};
OS Octadecabacter temperatus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Octadecabacter.
OX NCBI_TaxID=1458307 {ECO:0000313|EMBL:AKS45638.1, ECO:0000313|Proteomes:UP000067444};
RN [1] {ECO:0000313|EMBL:AKS45638.1, ECO:0000313|Proteomes:UP000067444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB1 {ECO:0000313|EMBL:AKS45638.1,
RC ECO:0000313|Proteomes:UP000067444};
RX PubMed=26358607;
RA Voget S., Billerbeck S., Simon M., Daniel R.;
RT "Closed Genome Sequence of Octadecabacter temperatus SB1, the First
RT Mesophilic Species of the Genus Octadecabacter.";
RL Genome Announc. 3:e01051-15(2015).
RN [2] {ECO:0000313|EMBL:SIN97356.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 26878 {ECO:0000313|EMBL:SIN97356.1};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000184809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26878 {ECO:0000313|Proteomes:UP000184809};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP012160; AKS45638.1; -; Genomic_DNA.
DR EMBL; FSRP01000001; SIN97356.1; -; Genomic_DNA.
DR RefSeq; WP_049834009.1; NZ_FSRP01000001.1.
DR AlphaFoldDB; A0A0K0Y3T0; -.
DR STRING; 1458307.OSB_10820; -.
DR KEGG; otm:OSB_10820; -.
DR PATRIC; fig|1458307.3.peg.1095; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000067444; Chromosome.
DR Proteomes; UP000184809; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000067444}.
FT DOMAIN 33..313
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 314..588
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 54..61
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 788 AA; 87894 MW; 89F200938F4EFDBD CRC64;
MSSYSDEDAF EGAIAKPSLS QQAMGMPQFD YLDGLNPAQR EAVEKLEGPV LMLAGAGTGK
TKALTCRIAH LLATNSARPD EILAVTFTNK AAREMKTRIG TLTNGVSEGM RWLGTFHAIC
VKQLRRHAEL VGLKTSFTIL DTDDQIRLLK QLVRAANIDE KRWPPRMLAG IIDGWKNKAW
LPSQVPVAES SAYDGMGVEL YTAYQQRLKE LNACDFGDLL LHMVTIFQTH ADILANYQRW
YKYILVDEYQ DTNVAQYMWL RLLAQGHKNI CCVGDDDQSI YGWRGAEVGN ILRFEKDFPG
AHVVRLEQNY RSTGHILGAA AGVIDANTNR LGKTLFTAGE DGEQVRLIGH MDGDTEARWI
GEEIESMQRG TRGLDPINLN SMAILVRASH QMRAFEDRFL TIGLPYRVIG GPRFYERLEI
RDALAYFRLA VSQDDDLAFE RIVNTPKRGL GDKAVQTIQV TARSNGVNLV EGARMCVESG
LIKGKGATAL KELVQGLDRW HRQLLDEADT HIELAGMILD ESGYTAHWQN TKTPEAPGRL
ENLKELVNGL EGFENLQGFL EHISLIMDNA KEENGDMVTI MTLHGSKGLE FPAVFLPGWE
EGIFPSQRSM DESGLKGLEE ERRLAYVGIT RAEKHCLISF VSSRQVFGRW QNQAPSRFID
ELPHKHVEVL PTTSQFGMGF GGEDDMAGSI HEKVASADVY NSPGWKRLQS RQQQRPTGQS
REARGTTIDM TATSSFTTGE RVFHQKFGYG EVIEIEGDKL VIEFDKAGEK KVVGKFIVSA
DKASDVPF
//
