ID A0A0K1F605_9ACTN Unreviewed; 450 AA.
AC A0A0K1F605;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=DNA repair protein {ECO:0000313|EMBL:AKT49976.1};
GN ORFNames=ADJ70_08780 {ECO:0000313|EMBL:AKT49976.1};
OS Olsenella sp. oral taxon 807.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=712411 {ECO:0000313|EMBL:AKT49976.1, ECO:0000313|Proteomes:UP000059853};
RN [1] {ECO:0000313|Proteomes:UP000059853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0089 {ECO:0000313|Proteomes:UP000059853};
RA Holder M.E., Ajami N.J., Petrosino J.F.;
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP012069; AKT49976.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K1F605; -.
DR STRING; 712411.ADJ70_08780; -.
DR KEGG; olo:ADJ70_08780; -.
DR PATRIC; fig|712411.3.peg.425; -.
DR OrthoDB; 9808813at2; -.
DR Proteomes; UP000059853; Chromosome.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11076:SF35; DNA REPAIR PROTEIN HOMOLOG YOBH; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
FT DOMAIN 10..199
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 450 AA; 49583 MW; B63A48D4BA3924BF CRC64;
MAAGCPERSY LAIDLKSFYA SVECVERGLD PLAARLVVAD LTRSEKTICL AVSPAMKALG
VRNRCRVFEI PRDIDHVTAR PRMALYIERS ADIYAVYLRY VSPEDIHVYS IDEAFLDVTG
YLRFYGCTAR ELGERIREDV VRTTGIPAAC GLGTNLYLAK IALDITAKHS PDFFGELDEG
SYRKTLWNHT PITDFWRVGA GTARRLARMG INTMGQVAAH PKEPLYQAFG VDAEILIDHA
WGVEPVTIAD IKAYRPQGKS LASGQVMFHD VSFDDGLLIA KEMADALVQE LVERRLACRS
LTLMVGYKLS SAQRQALRQA GGPEEHGGHV RWGELADGGT ATLPEPTCAL SGIWEALVPL
FRRVAKRGRL IHRLNLSLGD VRSEGTVGIQ ASLFTNEATC AREKSRQEVV GAIKRRFGRN
SLLRGMDLLP GAMARERNTQ IGGHRSGVEG
//
