ID A0A0K1NEI6_9BURK Unreviewed; 902 AA.
AC A0A0K1NEI6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=ADJ79_07335 {ECO:0000313|EMBL:AKU67086.1};
OS Ottowia sp. oral taxon 894.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Ottowia.
OX NCBI_TaxID=1658672 {ECO:0000313|EMBL:AKU67086.1, ECO:0000313|Proteomes:UP000056623};
RN [1] {ECO:0000313|Proteomes:UP000056623}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W10237 {ECO:0000313|Proteomes:UP000056623};
RA Holder M.E., Ajami N.J., Petrosino J.F.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP012073; AKU67086.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K1NEI6; -.
DR STRING; 1658672.ADJ79_07335; -.
DR KEGG; oto:ADJ79_07335; -.
DR PATRIC; fig|1658672.3.peg.1892; -.
DR Proteomes; UP000056623; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 730..746
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 852..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..869
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 656..663
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 902 AA; 96957 MW; 0A1685ED082F9A8B CRC64;
MPSQINQLAK KSVENHRLTD AEISSHTPMM QQYLRLKKDY PDTLLFYRMG DFYEMFYGDA
EKAAQLLDIT LTTRGQSAGQ PIPMAGVPFH SVESYLARLI RLGEAVAICE QVGEAGAAGA
GKGPVERKVV RVVTPGTLTD STLMAEKSES MLLAVHFGPR QQCGLAWLAV TQGQLNLAEC
AADDLPAWLA RIAPSEVLVS AGLTAAQQQR LEAALQTALQ TAQPAAPVTR RPEWQFDAAL
GAARLQEQLQ AASLAAWGAQ GCALAHAASA ALLAYAEHTQ GHALTHVRSL QVARAGDLID
LPAVTRRNLE LVQTLRGEDA PTLFSLLDTC QTGMGSRLLK TWLLAPQRDR AAASGRHAAI
AALLAPQGDA APLWQRLRAL LKGTGDVERV TARIALAQVR PRELAALRQA LQKSELPALA
AQAQAALLAQ LAQDLAPPAE CLQALQSAIA QEPAALVRDG GVIAPGHDAM LDELRAIASN
CDAFLLEMET RERQRTGIAN LRVQFNKVHG FYIEVTQGQA AKVPADYRRR QTLKNAERFI
TPELKAFEDR ALSAQERALA REKWLFDELL RRLQPHIPAL TRFARALAAL DALAALAERA
HTLEWRRPEF TREPGIDITA GRHPVVQARL QESGQGAFIA NSTHLGPRQR LQIITGPNMG
GKSTYMRQVA LITLLASMGS YVPAESCRLG PVDAIHTRIG AADDLANAQS TFMLEMTEAA
QILRSATPQS LVLMDEIGRG TSTYDGLSLA TAIAAWLHGK AQCLTLFATH YFELTELPAA
CHAAINVHVS AAETGEGGAI AFLHEIQPGP ASRSYGIQVA RLAGVPAAVV NHARHMLAKL
ETAAASQQAQ PDLFAPLPEP DPAPAAEPAP PSELQAALAA LEPDELSPRQ ALEALYQLKK
LA
//
