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Database: UniProt
Entry: A0A0K3ASP4_CAEEL
LinkDB: A0A0K3ASP4_CAEEL
Original site: A0A0K3ASP4_CAEEL 
ID   A0A0K3ASP4_CAEEL        Unreviewed;      1859 AA.
AC   A0A0K3ASP4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-SEP-2017, entry version 17.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cca-1 {ECO:0000313|EMBL:CTQ87048.1,
GN   ECO:0000313|WormBase:C54D2.5g};
GN   ORFNames=C54D2.5 {ECO:0000313|WormBase:C54D2.5g}, CELE_C54D2.5
GN   {ECO:0000313|EMBL:CTQ87048.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ87048.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CTQ87048.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ87048.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; BX284606; CTQ87048.1; -; Genomic_DNA.
DR   RefSeq; NP_001300337.1; NM_001313408.1.
DR   UniGene; Cel.19373; -.
DR   EnsemblMetazoa; C54D2.5g; C54D2.5g; WBGene00000367.
DR   GeneID; 181045; -.
DR   CTD; 181045; -.
DR   WormBase; C54D2.5g; CE50172; WBGene00000367; cca-1.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   ExpressionAtlas; A0A0K3ASP4; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    174    193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    267    290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    455       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    690    710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    778    799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    863    889       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1119   1137       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1157   1178       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1190   1209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1255   1277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1358   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1464   1485       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1497   1515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1527   1545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1594   1613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1682   1707       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      130    461       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      657    896       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1118   1390       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1463   1717       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      886    917       {ECO:0000256|SAM:Coils}.
FT   COILED     1052   1079       {ECO:0000256|SAM:Coils}.
FT   COILED     1381   1411       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1859 AA;  212362 MW;  FB7AC5E33E9C2DDD CRC64;
     MLRQPVPELR SFQSLSKYAG GPRSVLGRRT SAITVNRRQS QSTRRHEDVE ALGSIEGSKE
     TLQLSEHGRL ASSSEASPSR WEGRQIEWGN EEQIEEESEL PYPGFAEPAL RCFYQARPPR
     KWALQMVMSP WFDRITMAVI MINCVTLGMY RPCEDGPDCD TYRCQILDII DNCIFVYFAF
     EMVIKIMALG FYGPAAYMSD TWNRLDFFIV MAGIAEFVLH EYLGGNINLT AIRTVRVLRP
     LRAVNRIPSM RILVNLLLDT LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCVINLPK
     TISENQSALF NNVKLTRFYI PEDTSLEYIC SQPDANGLHT CSNLPPYTVD GVKCNLTLDE
     YDKVTNDSCI NWNIYYNECQ VMQRNPFQGS VSFDNIGFAW VAIFLVISLE GWTDIMYYVQ
     DAHSFWNWIY FVLLIVIGAF FMINLCLVVI ATQFAETKRR ETERMLQERK MLLNRDSISC
     TGSEIGGASS KEEGDTVYAA FVRFIGHTFR RTKRAAKKKY TAYMEERAER KSSERQQRRK
     SKLDDMATLS RIEEKAEDEE DETTITRENG DDQIEQNGDG VRIKRVKIEE EPKIKIGNGN
     SNGPHYKHSS SDEESDEDGE EDQVYDGEEA KKKSTPSKLW WFREKIQKFV ICDHFTRGIL
     VAILVNTLSM GVEYHQQPEI LTVILEYSNL FFTALFALEM LLKIIASGLF GYLADGFNLF
     DGGIVALSVL ELFQEGKGGL SVLRTFRLLR ILKLVRFMPA LRYQLVVMLR TMDNVTVFFG
     LLVLFIFIFS TLGMVLFGCK FCNHPDTGLQ CTSAQVISSI CECDRMNFDN FLFATVTVFQ
     ILTQEDWNMV LFNGMAQTNP WAALYFVALM TFGNYVLFNL LVAILVEGFQ ESKEEEKRQL
     EEDARKQAVE EEDERKRELE LIIAKTTSPA FNNGVAPAEC TCQRPSSPEE SPSPRLLSAN
     YHPSPERKHS ANLDAIIDKR LVLRNSAPFD RSPVSEGRDD SRLNRHASLV LPVANGVPYR
     RQRVHSWSGL CHHFNPNCPV HGRRALIETY AREKFLEASQ ELKQALAEEE KRNEAKQNTF
     VRKLLKKTCL HNRTEFSLFL MGPKNPLRIK CLQTTQKKWF DYTVLFFIGI NCITLAMERP
     SIPPDSFERQ FLHISGYIFT VIFTGEMMMK VIANGCFIGQ AAYFKDGWNI LDGILVVISL
     INIAFELLAT GDSPKIFGVI RVLRLLRALR PLRVINRAPG VKLVVMTLIS SLKPIGNIVL
     ICCTFFIIFG ILGVQLFKGM MYHCIGPEVG NVTTKADCIE DYRNKWVNHR YNFDNLGQAL
     MSLFVLSSKD GWVSIMYQGI DAVGVDVQPI ENYNEWRMIY FISFLLLVGF FVLNMFVGVV
     VENFHKCKEA LEKEMREKEK EKRLKRKLKR QKFEESMAGK RKKNRIVWAG SAIKSIFSVE
     RNYPYYHDYG HTRLFLHGIV TSKYFDLAIA AVIGINVISM AMEFYMMPMG LKYVLKALNY
     FFTAVFTLEA AMKLIALGFK RFFIEKWNRL DMFIVILSIA GIIFEEFEAL ELPINPTIIR
     VMRVLRIARV LKLLKMAKGI RSLLDTVGEA LPQVGNLGSL FFLLFFIFAA LGVELFGKLE
     CSEDHPCDGL GEHAHFKNFG MAFLTLFRIA TGDNWNGIMK DALRDDCDSS DHCETNCCVD
     PILAPCFFVI FVLISQFVLV NVVVAVLMKH LEESNKRDAE GPAEPTGENI ENEITKSDDD
     EIVEEHEPLA IEHVKEGELD EEEETEEGPT TQIPDGHGGI KRLSMQVLEQ ELIEVERHLE
     ERYRRASECL GGELQPLNPG EIEDLDDPEF RPRSRSHRPR ARTNSALSNK SRGSHKSAL
//
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