ID A0A0K3AUH0_CAEEL Unreviewed; 827 AA.
AC A0A0K3AUH0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=SH3 domain-containing protein {ECO:0000313|EMBL:CTQ86680.1};
GN Name=itsn-1 {ECO:0000313|EMBL:CTQ86680.1,
GN ECO:0000313|WormBase:Y116A8C.36e};
GN ORFNames=CELE_Y116A8C.36 {ECO:0000313|EMBL:CTQ86680.1}, Y116A8C.36
GN {ECO:0000313|WormBase:Y116A8C.36e};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ86680.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CTQ86680.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ86680.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CTQ86680.1; -; Genomic_DNA.
DR RefSeq; NP_001299979.1; NM_001313050.1.
DR AlphaFoldDB; A0A0K3AUH0; -.
DR SMR; A0A0K3AUH0; -.
DR PeptideAtlas; A0A0K3AUH0; -.
DR EnsemblMetazoa; Y116A8C.36e.1; Y116A8C.36e.1; WBGene00006405.
DR GeneID; 178491; -.
DR AGR; WB:WBGene00006405; -.
DR WormBase; Y116A8C.36e; CE50593; WBGene00006405; itsn-1.
DR OrthoDB; 2910300at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006405; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; A0A0K3AUH0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097708; C:intracellular vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0150007; P:clathrin-dependent synaptic vesicle endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR CDD; cd00174; SH3; 2.
DR CDD; cd11836; SH3_Intersectin_1; 1.
DR CDD; cd11837; SH3_Intersectin_2; 1.
DR CDD; cd11839; SH3_Intersectin_4; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF119; LD44138P; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50002; SH3; 5.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:A0A0K3AUH0,
KW ECO:0007829|PeptideAtlas:A0A0K3AUH0};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 403..464
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 522..581
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 624..682
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 701..764
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 767..827
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 191..265
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 27..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 92117 MW; 18EB9D92ADE10292 CRC64;
MCGISSRSAN NTPELEPGAE PPQKSPAPKT FEDKRQDNLS KGQAELERRR RVLEEEEQRR
RAEVEKKERE EEAKKNRERQ EKERQAEVER QAELERQRII EAQREEEEKK RRLEMERRRE
EDEKMRKVQM EKAKVKQMQN QKQQENERLA QRQQREKTLQ FQLQALDEKV IDVEVDIGKA
KEAVAEVTGF IERMRSTRDE KVARIKELQE TNQKFQTAIE SQELGHQLLQ KQSAHKETTQ
RKSELEALRR KRDAIRKAIE DAALELSTEK EKSYNQTEIL KTNKEKYKTD VYSKLVAKRE
EYRNSFELLV HAQTHARSKI GEFEAKSAPA SAAPAPAPAP APTTTNGFPA NFNDAFGEFD
KTDASQRFDA DFGATSTADP FAQIAQAPAH SKGAVDQSAF NIHDTYKCRA LFAFEARSED
ELSFEPGDVI IVFQSHAAEP GWRAGQLREK VGWFPEAFVE AIAAVPTPGG DPPIQNMPPN
MTPSSSVDQI GVKAARKAEI AAAMGLTEGG APPASSAPAA AAVISQCIAQ FQWRARNEED
LSFAKGDTIE VLEKQEMKWK GRNPAGEIGW FPKSYVKEVG ATTSTTTPIV SPSKASAGAP
GAAAGAQYDV VPSDVTLQAS ETAPQQQLYT VIYDFEAVET TDLALHVGDT ILVLEKNDEW
WKGRCNGREG IFPANYVEIS VQQAGDPTPP TQAPTPAAPP TVLCEAKVVV DFVASAPNQL
GIKVGEIVKI REKSAAGWWE GELIRNGKPI AGWFPGEYVK VLEEAASPAT RATAVYDYEA
SQPDELGFKT GDVIIVTDKS EAEWWSGHRE QDPSKSGLFP SNYVQQQ
//
