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Database: UniProt
Entry: A0A0K8PBU1_9CHLR
LinkDB: A0A0K8PBU1_9CHLR
Original site: A0A0K8PBU1_9CHLR 
ID   A0A0K8PBU1_9CHLR        Unreviewed;       603 AA.
AC   A0A0K8PBU1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=ATC1_12529 {ECO:0000313|EMBL:GAP39989.1};
OS   Flexilinea flocculi.
OC   Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC   Flexilinea.
OX   NCBI_TaxID=1678840 {ECO:0000313|EMBL:GAP39989.1};
RN   [1] {ECO:0000313|EMBL:GAP39989.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TC1 {ECO:0000313|EMBL:GAP39989.1};
RA   Matsuura N., Tourlousse D.M., Sun L., Toyonaga M., Kuroda K., Ohashi A.,
RA   Cruz R., Yamaguchi T., Sekiguchi Y.;
RT   "Draft Genome Sequence of Anaerolineae Strain TC1, a Novel Isolate from a
RT   Methanogenic Wastewater Treatment System.";
RL   Genome Announc. 3:e01104-15(2015).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR   EMBL; DF968180; GAP39989.1; -; Genomic_DNA.
DR   RefSeq; WP_062278867.1; NZ_DF968180.1.
DR   AlphaFoldDB; A0A0K8PBU1; -.
DR   STRING; 1678840.ATC1_12529; -.
DR   PATRIC; fig|1678840.3.peg.1133; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000053370; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000053370}.
FT   DOMAIN          208..326
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          416..557
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   603 AA;  66725 MW;  2762C1A6BAA1340A CRC64;
     MAIRILADEV VSQIAAGEVI ERPASVVKEL IENAIDAGAS AIMIRTEEAG KRIIEIIDNG
     CGIQSDELEK AVMRHATSKL TNAEDLFHIH TLGFRGEALA AAGSVSRMRI TTCTAEGNNG
     YSITVDGGKI TGIHQTGTKQ GTIVQVTDLF YNVPARLKFL KSDVTERNQI EILISRYALA
     YPNIRWQSTH DGKPGIRTTG NADYREVLTA IYGVDIAKKL IEIDLKEEGI SVFGFISPVA
     LTRSNRREMN FFVNGRWIQD VQLNSAIIRA YQSLIMVGRY PIAALFISMD PEEVDVNVHP
     SKAEVRFRSP DKVFGIVHRA VRRSLIFQSP VPEIHSNAQW PGWHAPANPQ SNDNELTTVV
     DNPAEGIPVA FWRTELPQNQ IPPNNSIPAG SSSAILQPQS NFQTAPINPG FPILRWIGQI
     GGTYVIAEGP DGLYLIDQHA AHERILFEKL MGQVDSRIAS QSLLEPAIVQ VSAWQTSLLE
     ENMDILTRLG FRIELFGPAT YRILSIPEIF TKGNPAAAVR SIVEDFEEDE TPLQSEIEKR
     IAGRICKSMA VKAGQPLSEE EQRGLIRDLE NCQSPRTCPH GRPTMIHLSI HLLERQFGRK
     GTI
//
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