ID A0A0K9ETU0_9ACTO Unreviewed; 144 AA.
AC A0A0K9ETU0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Fur family ferric uptake regulator {ECO:0000313|EMBL:VDG75325.1};
DE SubName: Full=Fur family transcriptional regulator {ECO:0000313|EMBL:KMY23285.1, ECO:0000313|EMBL:SDE09045.1};
GN Name=fur_1 {ECO:0000313|EMBL:VDG75325.1};
GN ORFNames=ACU19_04710 {ECO:0000313|EMBL:KMY23285.1}, NCTC10327_00052
GN {ECO:0000313|EMBL:VDG75325.1}, SAMN05421878_10245
GN {ECO:0000313|EMBL:SDE09045.1};
OS Actinobaculum suis.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinobaculum.
OX NCBI_TaxID=1657 {ECO:0000313|EMBL:KMY23285.1, ECO:0000313|Proteomes:UP000037036};
RN [1] {ECO:0000313|Proteomes:UP000037036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=U311 {ECO:0000313|Proteomes:UP000037036};
RA Moreno L.Z., Amigo C.R., Gobbi D.S., Ferreira T.S., Santos A.P.,
RA Moreno A.M.;
RT "Draft genome sequences of Brazilian Actinobaculum suis isolated from urine
RT and preputial swab.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KMY23285.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=U311 {ECO:0000313|EMBL:KMY23285.1};
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000182744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20639 {ECO:0000313|Proteomes:UP000182744};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:SDE09045.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20639 {ECO:0000313|EMBL:SDE09045.1};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:VDG75325.1, ECO:0000313|Proteomes:UP000269974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10327 {ECO:0000313|EMBL:VDG75325.1,
RC ECO:0000313|Proteomes:UP000269974};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-1};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602481-1};
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000256|ARBA:ARBA00007957}.
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DR EMBL; LFUS01000023; KMY23285.1; -; Genomic_DNA.
DR EMBL; FNAU01000002; SDE09045.1; -; Genomic_DNA.
DR EMBL; UYIO01000001; VDG75325.1; -; Genomic_DNA.
DR RefSeq; WP_049619568.1; NZ_LFUS01000023.1.
DR AlphaFoldDB; A0A0K9ETU0; -.
DR STRING; 1657.ACU20_04525; -.
DR PATRIC; fig|1657.3.peg.957; -.
DR Proteomes; UP000037036; Unassembled WGS sequence.
DR Proteomes; UP000182744; Unassembled WGS sequence.
DR Proteomes; UP000269974; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202:SF18; TRANSCRIPTIONAL REGULATOR FURA; 1.
DR PANTHER; PTHR33202; ZINC UPTAKE REGULATION PROTEIN; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602481-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000182744};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR602481-1}.
FT BINDING 92
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 95
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 132
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
FT BINDING 135
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
SQ SEQUENCE 144 AA; 16094 MW; 6E31F925A9674C9E CRC64;
MGTDFTRMLR DAGLRATEPR LAVLREVDKG GHLSAEQLRA GVIEQLGSVS VQAIYDIVHT
LTEKGILRKM QPTSNVTMYE LNLQDNHHHM ICRSCGKIVD VPCPRAAAPC LLPADPRGWE
IDEAEITFWG YCPECQEARH APEE
//
