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Database: UniProt
Entry: A0A0K9PQI8_ZOSMR
LinkDB: A0A0K9PQI8_ZOSMR
Original site: A0A0K9PQI8_ZOSMR 
ID   A0A0K9PQI8_ZOSMR        Unreviewed;       226 AA.
AC   A0A0K9PQI8;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   08-NOV-2023, entry version 26.
DE   RecName: Full=Ubiquitin thioesterase OTU {ECO:0000256|RuleBase:RU367104};
DE            EC=3.4.19.12 {ECO:0000256|RuleBase:RU367104};
GN   ORFNames=ZOSMA_19G00890 {ECO:0000313|EMBL:KMZ70505.1};
OS   Zostera marina (Eelgrass).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Zosteraceae; Zostera.
OX   NCBI_TaxID=29655 {ECO:0000313|EMBL:KMZ70505.1, ECO:0000313|Proteomes:UP000036987};
RN   [1] {ECO:0000313|Proteomes:UP000036987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Finnish {ECO:0000313|Proteomes:UP000036987};
RX   PubMed=26814964; DOI=10.1038/nature16548;
RA   Olsen J.L., Rouze P., Verhelst B., Lin Y.-C., Bayer T., Collen J.,
RA   Dattolo E., De Paoli E., Dittami S., Maumus F., Michel G., Kersting A.,
RA   Lauritano C., Lohaus R., Toepel M., Tonon T., Vanneste K., Amirebrahimi M.,
RA   Brakel J., Bostroem C., Chovatia M., Grimwood J., Jenkins J.W.,
RA   Jueterbock A., Mraz A., Stam W.T., Tice H., Bornberg-Bauer E., Green P.J.,
RA   Pearson G.A., Procaccini G., Duarte C.M., Schmutz J., Reusch T.B.H.,
RA   Van de Peer Y.;
RT   "The genome of the seagrass Zostera marina reveals angiosperm adaptation to
RT   the sea.";
RL   Nature 530:331-335(2016).
CC   -!- FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins
CC       and may therefore play an important regulatory role at the level of
CC       protein turnover by preventing degradation.
CC       {ECO:0000256|RuleBase:RU367104}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU367104};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367104}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KMZ70505.1}.
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DR   EMBL; LFYR01000728; KMZ70505.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0K9PQI8; -.
DR   STRING; 29655.A0A0K9PQI8; -.
DR   OMA; YIPEHEY; -.
DR   OrthoDB; 1201at2759; -.
DR   Proteomes; UP000036987; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   CDD; cd22759; OTU_plant_OTU3-like; 1.
DR   Gene3D; 3.90.70.80; -; 1.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR13312; HIV-INDUCED PROTEIN-7-LIKE PROTEASE; 1.
DR   PANTHER; PTHR13312:SF3; OVARIAN TUMOR DOMAIN-CONTAINING DEUBIQUITINATING ENZYME 3; 1.
DR   Pfam; PF02338; OTU; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50802; OTU; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|RuleBase:RU367104};
KW   Hydrolase {ECO:0000256|RuleBase:RU367104};
KW   Protease {ECO:0000313|EMBL:KMZ70505.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036987};
KW   Thiol protease {ECO:0000256|RuleBase:RU367104};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU367104}.
FT   DOMAIN          71..226
FT                   /note="OTU"
FT                   /evidence="ECO:0000259|PROSITE:PS50802"
SQ   SEQUENCE   226 AA;  25433 MW;  A2A55F02575F7E92 CRC64;
     MGLAGSPSND VILGRLMNGI ESFEIIVNGD SSNHNVSYSN ALFTHNCIPT GRPFARIGRP
     LGEAVRKVEH YNVRKITGDG RCMFRALAKG MAANKGITLN MRQETNDADE LRIAVKEVIC
     NSEEERHKYE EAIIAITVDE SLKQYCQRIQ RCNFWGGESE LLVLSRLCRQ SIIVYIPEHE
     YTRGHRGGVI PIAEYGVEFI KGGKNVKPRK PVRLLYSGKN HYDLLL
//
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