ID A0A0K9Q1L3_ZOSMR Unreviewed; 1129 AA.
AC A0A0K9Q1L3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=ZOSMA_11G00720 {ECO:0000313|EMBL:KMZ75049.1};
OS Zostera marina (Eelgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Zosteraceae; Zostera.
OX NCBI_TaxID=29655 {ECO:0000313|EMBL:KMZ75049.1, ECO:0000313|Proteomes:UP000036987};
RN [1] {ECO:0000313|Proteomes:UP000036987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Finnish {ECO:0000313|Proteomes:UP000036987};
RX PubMed=26814964; DOI=10.1038/nature16548;
RA Olsen J.L., Rouze P., Verhelst B., Lin Y.-C., Bayer T., Collen J.,
RA Dattolo E., De Paoli E., Dittami S., Maumus F., Michel G., Kersting A.,
RA Lauritano C., Lohaus R., Toepel M., Tonon T., Vanneste K., Amirebrahimi M.,
RA Brakel J., Bostroem C., Chovatia M., Grimwood J., Jenkins J.W.,
RA Jueterbock A., Mraz A., Stam W.T., Tice H., Bornberg-Bauer E., Green P.J.,
RA Pearson G.A., Procaccini G., Duarte C.M., Schmutz J., Reusch T.B.H.,
RA Van de Peer Y.;
RT "The genome of the seagrass Zostera marina reveals angiosperm adaptation to
RT the sea.";
RL Nature 530:331-335(2016).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMZ75049.1}.
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DR EMBL; LFYR01000216; KMZ75049.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K9Q1L3; -.
DR STRING; 29655.A0A0K9Q1L3; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000036987; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000036987};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..314
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 695..1083
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1129 AA; 127307 MW; 5BE0E545F2177660 CRC64;
MEKKLNAWIP YVESFVSSPT SLNADDITAV SKLVNTGFLC LEDLVKDMEL YLTSTDHFIR
NRGVTLLAEV VGHLQSKPLS STTIHSLINY FSLRLADWHA LHGALIGCLT LLRRKHEVGR
VVDNDASALA DSFLKNIQVQ LLALQDRKLC FEILVSLLDD YSEVMIVLDE FLISGICQAI
DNEKDPTCLM LTFHIVQSLV QIFPDPSGPI ASAAEDLFEI LSCYFPIYFT HPKSDHIDIK
RDDLSIVLMN AFCSTPLFEP FAVNLLLEKL SAHLPSSKID SLRYLNKCIL NYGANRMEKY
CKSIWYSLKE TIFNYSPFES LSESGSYHDS QENQIFKEAS LCLQTALTLQ SVKGKSFITW
IIEDKDFDIC VSSVANEICY ETLSVESRRL LNGTRTILCL CAKAYDQCCD RAFHSFFPRL
MDILGIFPCN ASLDVGSLEN ISSRSLCFGA LYLSIEMLAS GRDLVLSYKQ FPESISGENK
WFQLVQNIYS PLSYAIGSLV RKHGFKEKNN ITEDINSAVK GLQVLATFPE KLHVSVFVFE
YILGIFVSII TGSSKDSDLW KLSLKSLVQI GLFIENSRCP ETKTVYVSLV MEKIISLMKC
NDSNMTLAMK LEAVFSIGST NPVYMSRAIR DLEMQIFGNF VEIFVVGNQS FDPTFVRLLD
CYTSQVLTWC NIKGNYDEVA MHFVLYIWNQ MESVSISSIK SQQDVFDSLI MTMKVVVGNL
NKENQLLIMH KGYNIIQSRI ISPLRKLNQF LPDNTEIARL DLDSIILSPY DELLVSLFAA
VVVALQPQVV ISDIKVIINV FSIYLLKGHV SAAHALGSIF NKWPSNSKKA DEISCRLEEA
IDIIFTKGVF SSDIKLLRIN DDIDANNAVH MNVIVGLGWI GKGLLMCGHQ KMKDIMMVLF
KYMLTNNCAE SRLPNSDVMG NFTSPVLSRS AADAFSIIMS DSDACLNKKF HAMIRPLYKQ
RFFSSVLTIL LSSIKDSNIS DVRNSLYHAF GHVISNTPIA ALLLETKKLI LPLFECLSSL
SADCKNNDLL YSILLVFSSI LMENTGKCVV IENVHIIINP LLELAFYPYM MLVRETAIQC
LVAMSEFPHA RIYPIRQQVL KAMHKALDDP KRPVRLEAVR CRWRWESIA
//
